急性白血病患儿外周血T淋巴细胞亚群和NK细胞水平测定及临床意义

为探讨急性白血病患儿外周血T淋巴细胞亚群和NK细胞水平及意义 ,采用流式细胞技术测定 90例急性白血病患儿外周血T淋巴细胞亚群和NK细胞水平。结果 ,急性白血病患儿外周血T淋巴细胞亚群中CD3+ 、CD4+ 、CD4+ CD8+ 均明显低于对照组水平 (P <0 0 1) ,CD8+ 高于对照组水平 (P <0 0 1) ,NK细胞 (CD1 6+ 56+ )明显低于对照组水平 (P <0 0 1) ,经治疗缓解者T淋巴细胞亚群和NK细胞达正常水平。结果表明 ,T淋巴细胞亚群和NK细胞可作为急性白血病辅助诊断指标 ,为临床治疗提供实验依据

Clinical significance and measurement of T lymphocyte subsets and natural killer cell levels in peripheral blood of children with acute leukemia

To investigate the clinical significance and measurement of T lymphocyte subset s and natural killer cell levels in peripheral blood of children with acute leuk emia. Methods: The levels of T lymphocyte subsets and natural killer cell were determined by using flow cytometry analysis in 90 children with acute leukemia. Results: CD 3 +? CD 4 + and CD 4 +/ CD 8 + ratio of T lym phocyte subsets of children with acute leukemia were significantly lower than th ose of control group( P <0 01), CD 8 + was significantly higher than t hat of control group( P <0 01), CD 16+56 +(natural killer cell) wa s significantly lower than that of control group( P <0 01). The result of T lymphocyte subsets and natural killer cell of the cured patients after remission recovered to normal levels. Conclusion: T lymphocyte subsets and natural killer cell can be used as the assistance index of diagnosis and provide experimental b asis for the clinic therapy to acute leukemia.