| 头孢哌酮中间体7-TMCA 盐酸盐合成工艺的改进 |
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| 引用本文： | 高晓荣,李俊波,魏文珑,常宏宏. 头孢哌酮中间体7-TMCA 盐酸盐合成工艺的改进[J]. 中国现代应用药学, 2009, 26(10): 832-834 |
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| 作者姓名： | 高晓荣 李俊波 魏文珑 常宏宏 |
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| 作者单位： | 1.太原科技大学化学与生物工程学院，太原 030021；2.长治医学院药学系化学教研室，山西 长治 046000；3.太原理工大学化学化工学院，太原 030024 |
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| 摘 要： | 目的对抗生素头孢哌酮中间体7-TMCA盐酸盐的合成方法进行改进。方法以1-甲基-5-巯基四氮唑和7-氨基头孢烷酸为原料，采用三氟化硼乙腈络合物催化合成7-TMcA盐酸盐，并通过均匀试验对合成工艺进行了优化。结果合成产物经熔点、IR确证，收率为92．0％。结论此方法收率高，产品纯度好，适合工业化生产。
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| 关 键 词： | 头孢哌酮 7-TMCA盐酸盐 三氟化硼乙腈络合物 |
| 收稿时间： | 1900-01-01 |
Study on the Basic Elements of Rational Use of Traditional Chinese Medicine Injections |
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| GAO Xiaorong,LI Junbo,WEI Wenlong,CHANG Honghong. Study on the Basic Elements of Rational Use of Traditional Chinese Medicine Injections[J]. The Chinese Journal of Modern Applied Pharmacy, 2009, 26(10): 832-834 |
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| Authors: | GAO Xiaorong LI Junbo WEI Wenlong CHANG Honghong |
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| Affiliation: | 1.College of Chemistry and Biological Engineering, Taiyuan University of Science and Technology, Taiyuan 030021,China; 2.Department of Chemistry, the Department of Pharmacology, Changzhi Medical College, Changzhi 046000, China; 3.College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China |
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| Abstract: | Rational use of traditional Chinese medicine injection is widely attention and attaching great importance. The basic elements on rational use of traditional Chinese medicine injections include security, validity, economy and propriety. Security is the bas |
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| Keywords: | traditional Chinese medicine injection rational use of drug the basic element |
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