兰索拉唑与雷尼替丁联用抗生素治疗幽门螺杆菌阳性十二指肠溃疡的疗效对比

目的：比较兰索拉唑与雷尼替丁联用抗生素治疗幽门螺杆菌（Helicobacter pylori,Hp)阳性十二指肠溃疡的疗效。方法：将经内窥镜证实的105例Hp阳性十二指肠溃疡患者随机分为两组，分别给予口服兰索拉唑和雷尼替丁（均联用抗生素）治疗。于停药后1个月。于停药后1个月、1年复查内窥镜及Hp检测，并作随访观察1年。结果：治疗组与对照组对十二指肠溃疡的愈合率分别为94．44％和74．51％，好转率分别为5．56％和25．49％。Hp根除率分别为90．74％和56．86％（P＜0．01）。随访1年后，治疗组的十二指肠溃疡复发率为3．70％，对照组复发率为21．57％，根除Hp者中溃疡复发率为2．56％，未根除Hp者中溃疡复发率为30．30％（P＜0.01)。结论：兰索拉唑对Hp阳性十二指肠溃疡的Hp根除和溃疡愈合有较高的成功率。

Comparison of Efficiency between Lansoprazole and Ranitidine Combined with Antibiotics in Treatment Helicobacter Pylori Positive of Duodenal Ulcer

Objective: To compare the efficiency of lansoprazole and ranitidine, combined with antibiotics, in treatment of helicobacter pylori(H. pylori) positive duodenal ulcer. Methods: 105 patients with duodenal ulcer of H. pylori positive evidenced by gastroscopy were randomizly divided into two groups,treatment group (lansoprazole) and control group(ranitidine), antibiotics were given simultaneously in the two groups. Gastroscopy was performed and H. pylori was tested 1 month, 1 year after therapy and patients were followed up for 1 year. Results: The healing rate of ulcer was 94.44% ,74. 51% ,better rate was 5.56% and 25.49% , H. Pylori eradicating rate was 90.74% and 56.86% in treatment group and control group,respectively (P<0.01). After 1 year follow - up,recurrence rate of duodenal ulcer was 3. 70% in treatment group and 21. 57% in control group,2.56% in the patients with H. pylori negative,and 30.30% in the patients with H. pylori positive(P<0.01). Conclusion: Lansoprazole has the higher rate of eradicating H. pylori and enhanced healing of the ulcer in the treatment of duodenal ulcer with H. pylori positive.