| 骨痛灵软膏镇痛作用的药理研究 |
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| 引用本文： | 李兴志,李贺,睢大员,于晓风,曲绍春. 骨痛灵软膏镇痛作用的药理研究[J]. 吉林大学学报(医学版), 2004, 30(2): 201-203. DOI: 国家九五科技攻关课题 |
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| 作者姓名： | 李兴志 李贺 睢大员 于晓风 曲绍春 |
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| 作者单位： | 1. 吉林大学第一医院康复疼痛诊疗中心，吉林 长春 130021；2. 吉林大学药学院药理学教研室，吉林 长春 130021 |
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| 摘 要： | 目的：观察骨痛灵软膏(GTLO)的镇痛作用及对血液黏度的影响。方法：通过小鼠扭体法致痛、热板法致痛、大鼠辐射热照射法致痛试验及急性血瘀模型大鼠血液黏度试验，对GTLO的镇痛和改善血液黏度作用进行药理研究。结果：GTLO对小鼠扭体法及热板法致痛，大鼠辐射热照射法致痛均具有明显抑制作用，并能明显降低急性血瘀模型大鼠的血浆黏度。结论：GTLO对多种疼痛模型均具有明显的抑制作用，并能改善急性血瘀模型大鼠的血浆粘滞性。
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| 关 键 词： | 镇痛药 治疗应用 血液黏度 疾病模型 动物 |
| 文章编号： | 1671-587X(2004)02-0201-03 |
| 收稿时间： | 2003-10-18 |
| 修稿时间： | 2003-10-18 |
Pharmacological research on analgesic effect of Gutongling ointment |
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| LI Xing zhi ,LI He ,SUI Da yuan ,YU Xiao feng ,QU Shao chun. Pharmacological research on analgesic effect of Gutongling ointment[J]. Journal of Jilin University: Med Ed, 2004, 30(2): 201-203. DOI: 国家九五科技攻关课题 |
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| Authors: | LI Xing zhi LI He SUI Da yuan YU Xiao feng QU Shao chun |
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| Affiliation: | 1. Center of diagnosis and treatment for ache and healing,First Hospital, Jilin University, Changchun 130021, China;2.Department of Pharmacology, College of Pharmacy, Jilin University, Changchun 130021,China |
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| Abstract: | ObjectiveTo investigate the analgesic effect of Gutongling ointment (GTLO) and its effect on viscidity of blood. MethodsAnalgesic effect of GTLO and its effect on viscidity of blood were carried through ache models induced by wring body and hot board methods in mice, by irradiation method of radiant heat in rats and test of viscidity of blood in rats with acute stasis of blood. ResultsGTLO had significant inhibitory action on ache models induced by wring body and hot board methods in mice and by irradiation method of radiant heat in rats, moreover it could reduce significantly viscidity of plasma in rats with acute stasis of blood. ConclusionGTLO has significant inhibitory effect on many experimental ache models and can improve significantly viscidity of plasma in rats with acute stasis of blood. |
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| Keywords: | Gutongling ointment analgesics/therapeutic use blood viscidity disease models animal |
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