视黄醇结合蛋白-4与初诊2型糖尿病患者血脂及胱抑素C的关系

目的：探讨视黄醇结合蛋白-4（RBP-4）与初诊2型糖尿病（T2DM）患者血脂及胱抑素c（Cysc）的关系。方法：选取T2DM（T2DM组）患者85例，体检健康者（对照组）65例，测定两组空腹血糖（FPG）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDL—C）、RBP-4及游离脂肪酸（FFA），计算体重指数（BMI）及腰臀比（WHR），并作相关性分析，同时测定不同阶段糖尿病肾病患者的RBP-4及Cysc水平。结果：与对照组比较，T2DM组BMI、FPG、TG、LDL—C、RBP-4及FFA明显升高，但HDL—C明显降低，差异均有统计学意义（P〈0．05）。RBP-4与FPG、BMI、TG及总胆固醇（TC）均呈正相关，FFA是影响血清RBP-4水平的明显因素。T2DM组患者Cysc及RBP-4水平均明显高于正常对照组，差异有统计学意义（P〈0．05）。随着T2DM尿蛋白含量的增加，其Cysc及RBP-4水平明显上升。结论：T2DM患者RBP-4水平与血脂水平正相关，而RBP与Cysc同时检测可作为评价肾功能受损程度及部位的指标。

Relationship of retinol binding protein 4 with hyperlipidemia and cystatin C in the patients with newly-diagnosed type 2 diabetes

Objective.- To evaluate the relationship of retinol binding protein 4（RBP-4） with hyper- lipidemia and cystatin C（Cysc） in the patients with newly-diagnosed type 2 diabetes. Methods： Serum sam- ple were taken from 85 patients with T2DM, and 65 normal controls. FPG, TG, HDL-C, LDL-C, RBP- 4, FFA, BMI and WHR were measured. Spearman analysis and Logistic analysis were used. RBP-4 and Cysc at different stage of diabetic nephropathy were measured. Results; Compared the control group, BMI, FPG, TG, LDL-C, RBP-4 and FFA of the T2DM group were significantly increased, but the HDL- C was significantly reduced（P〈0.05）. RBP-4 was positively correlated FPG, BMI, TG and TC.FFA was the strongest influencing factor of RBP-4 concentration. The level of the Cysc and RBP-4 of the T2DM group were significantly higher than those of the control group（P〈0.05）. With the increase of uri- nary protein of T2DM , the Cysc and RBP-4 level rise obviously. Oonclusions： RBP-4 of the T2DM was positively correlated with hyperlipidemia, and RBP and Cysc could be taken as the indicators for evaluating the extent and location of diabetic nephropathy.