显微外科手术治疗急性期的颅内动脉瘤疗效及其对炎症因子水平的影响

目的：探讨显微外科手术治疗急性期颅内动脉瘤的临床疗效及其对炎症因子水平的影响。方法：选取于我院治疗的颅内动脉瘤患者176例，随机分为两组，对照组和观察组各88例，观察组行急性显微外科手术治疗，对照组给予血管内介入栓塞术治疗，比较两组术后的疗效、并发症发生情况差异；比较术前及术后两组间脑脊液中白介素-1（IL-1）、白介素-6（IL-6）、内皮素-1（ET-1）、肿瘤坏死因子-αa（TNF—α）水平差异；1年后随访，进行GoS预后评分，比较预后差异。结果：手术后观察组完全栓塞率高于对照组，并发症总发生率则低于对照组，差异具有统计学意义（P％0．05）；术后1、3、7d，观察组脑脊液中IL-1、IL-6、ET-1、TNF—α水平均低于对照组，差异均具有统计学意义（P〈0．05）；随访1年观察组中81例恢复良好，达到92．05％，而对照组仅79．55％恢复良好，差异具有统计学意义（P〈0．05）。结论：早期进行显微外科手术治疗动脉瘤能改善患者预后，提高生活质量，疗效优于血管内介入栓塞术。

Effects of microsurgical treatment for acute intracranial aneurysms and its influence on the levels of inflammatory factors

Objective： To investigate the clinical curative effect of microsurgical treatment for acute intracranial aneurysms and its influence on the levels of inflammatory factors. Methods：A total of 176 pa- tients with intracranial aneurysms were randomly divided into control group（intravascular interventional embolization treatment group, n = 88） and observation group （acute microsurgical operation treatment group, n=88 cases）,then the efficacy, complications of two groups were compared. And the levels of IL- 1.IL-6.ET-1.TNF-ain CSF before and after the treatment were compared. Results：The incidence of cornpletely embolism of the observation group was higher than that of the control group, but the rate of com- plications was significantly lower. 1,3,7 days after undergoing surgery the levels of IL-1. IL-6. ET-1. TNF-α in CSF of the observation group were all lower than those in control group. I-year follow-up showed 81 cases （92.05%） in the observation group had good recovery, while only 79.55% cases of the control group did the same, showing significant difference （P〈0.05）. Oonclusion.Early mierosurgery surgical an- eurysm treatment can improve prognosis of patients with acute intracranial aneurysms, improve the quali- ty of life, and it is more effective than intravascular interventional embolization.