进展性脑梗死患者的血凝和炎性因子hs-CRP检测的临床意义

目的：探讨进展性脑梗死患者的血凝和炎性因子超敏C反应蛋白（hs—CRP）检测的临床意义，为临床诊断和治疗提供参考。方法：选择我院2010年10月-2012年10月收治的60例进展性脑梗死患者作为观察组，同时选取体检健康者60例作为对照组，检测并比较两组凝血酶原时间（PT）、凝血酶时间（TT）、纤维蛋白原（Fg）、部分凝血活酶时间（APTT）、抗凝血酶3（AT3）、蛋白C（PC）、蛋白S（PS）等指标和炎症因子hs—CRP的变化情况。结果：观察组的PT、APTT、TT等指标均明显低于对照组，而Fg则明显高于对照组，差异具有统计学意义（P均〈0．05）；观察组的AT3、PC、PS等抗凝指标均较对照组明显降低，差异具有统计学意义（P均〈0．05）；观察组的hs—CRP水平明显高于对照组，差异具有统计学意义（P〈0．05）。结论：血凝相关指标和炎症因子hs—CRP水平可作为进展性脑梗死严重程度的一种参考因素，其在一定程度上提示了进展性脑梗死患者的病情和预后。

Clinical significance of coagulation and inflammatory factors hs-CRP in treating patients with progressive cerebral infarction

Objective. To investigate the clinical significance of coagulation and inflammatory fac- tors hs-CRP in treating patients with progressive cerebral infarction. Methods. A total of 60 cases of pro- gressive cerebral infarction patients were selected as observation group, and another 60 healthy persons served as control group. PT （prothrombin time）, TT （thrombin time）, Fg （fibrinogen）, APTT （activa- ted partial thromboplastin time）, AT3 （antithrombin）, PC （protein C）, PS （protein S） and inflammatory factors and other indicators of changes in hs-CRP were detected. Results. PT, APTT, TT and other indicators in observation group were significantly lower than that of control group, while Fg was significantly higher than that of control group （P〈0.05）. AT3, PC, PS and other anticoagulant indicators were signif- icantly lower in observation group than those of control group （P〈 0.05）. Patients in the observation group had significantly higher hs-CRP levels （P〈0.05）. tors related indicators hs-CRP levels can be a indicator for Conclusion： Coagulation and inflammatory fac- assessment of progressive cerebral infarction se- verity, which suggests patient＇s condition and prognosis at a certain extent.