原发性男性高血压患者血尿酸与超敏C反应蛋白相关性分析

目的：探讨男性原发性高血压患者血尿酸与超敏C反应蛋白水平在病情进展中变化的相关性。方法：随机选择男性原发性高血压患者150例，1、2、3级患者各50例，检测并比较其血尿酸和超敏C反应蛋白水平，同时设立健康对照组。结果：1、2、3级原发性高血压患者尿酸和超敏C反应蛋白水平均高于健康对照组，差异有统计学意义（P〈0．05），随血压级别的升高，血尿酸和超敏C反应蛋白水平均同步升高，差异有统计学意义（P〈0．05）；1、2级，2、3级，1、3级之间血尿酸比较差异有统计学意义（P〈0．05），3级患者超敏c反应蛋白较1、2级明显增高，差异有统计学意义（P〈0．05）。结论：男性原发性高血压患者尿酸和超敏C反应蛋白水平明显增高，且二者有明显相关性，尿酸对超敏C反应蛋白具有促进作用。二者可能与高血压发生的血管炎症和损伤因素有关，有效控制血压可明显降低血尿酸和超敏C反应蛋白水平。

Correlation between uric acid and high-sensitivity C-reactive protein level in male patients with primary hypertension

Objective： To explore the correlation between uric acid and high-sensitivity C-reactive protein （hs-CRP） level in male patients with primary hypertension. Methods： One hundred and fifty male patients with primary hypertension in stage I （n=50）, 11 （n=50） and 111 （n=50）were selected. The lev- els of uric acid and hs-CRP were detected and compared with healthy control group. Results： The levels of uric acid and hs-CRP in each group was significantly higher than that of healthy control group（P〈0.05）. The levels of uric acid and hs-CRP were significantly increased along with rising hypertension（P〈0.05）. There was significant difference in hs-CRP between patients at different stage. And increase in hs-CRP of patients at stage III was more significant than those at stages I and II （P〈0. 05）. Conclusion： Male pa- tients with primary hypertension have significantly increased uric acid and hs-CRP levels, which are closely associated with hypertension. induced vascular inflammation reduced by effective control of Uric acid can increase hs-CRP level, they may be related with hypertension- and damage. Moreover, the levels of uric acid and hs-CRP can be obviously hypertension.