肝硬化患者血清胆汁酸检测分析

目的：研究肝硬化患者血清胆汁酸的变化情况，探讨血清胆汁酸对肝硬化病情程度的评估作用。方法：以59例健康体检人员为对照，比较89例不同Child—pugh分级肝硬化患者各肝功能指标情况，研究各肝功能指标Child—pugh评分的相关性。结果：肝硬化组与对照组血清总胆汁酸（TBA）、总胆红素（TBIL）、谷丙转氨酶（ALT）、谷草转氨酶（AST）水平差异均有统计学意义（P〈0．05），肝硬化组各肝功能指标均出现不同程度升高；不同Child—pugh分级肝硬化组任意两组TBA、TBIL水平比较差异均有统计学意义（P〈0．05），B级组ALT水平与c级组比较差异无统计学意义（P〉0．05），A级组AST水平与B级组比较差异无统计学意义（P〉0．05）；TBA、TBIL与Child—pugh评分均呈正相关（r=0．692、0．529，P〈0．05）。结论：血清TBA与Child—pugh评分有较好的相关性，能准确反映肝硬化患者的病情严重程度，对肝硬化的早期诊断、病情评估均有重要的临床应用价值。

Analysis of serum total bile acid in patients with liver cirrhosis

Objective： To study the changes of serum bile acid in patients with liver cirrhosis, and to explore the role of serum bile acid in evaluation of liver cirrhosis severity. Methods： A total of 59 healthy volunteers served as control group, 89 patients with cirrhosis at different Child-pugh classification were selected as cirrhosis group. Correlation between indexes of liver function and Child-pugh score was analyzed. Results. There were significant differences in TBA, TBIL, ALT and AST between two groups （P〈0.05） ,and all indexes in cirrhosis group were increased at different degree; The differences in TBA, TBIL were significant among groups at different Child-pugh classification （P〈0.05）. The difference in ALT was not significant between B and C grade level significant between group A and B grade level group group （P〈 0.05）, and the difference in AST was not （P〉0.05）〈 TBA （r=0. 692, P〈0.05）, TBIL （r=0. 529,P〈0.05） and Child-pugh score was positively correlated. With Child-pugh score. It can reflect the severity of cirrhosis, and rhosis and condition assessment. Conclusion. Serum is valuable in early TBA has diagnosis correlation of liver cir