白藜芦醇对D-半乳糖致衰老小鼠氧化损伤的影响

目的研究白藜芦醇对D-半乳糖所致衰老小鼠氧化损伤的缓解作用.方法用D-半乳糖皮下注射制备衰老小鼠模型,同时分别给予不同剂量白藜芦醇(15、30 mg/kg)灌胃,观察其对衰老模型小鼠血清和脑组织抗氧化系统的影响.结果衰老模型小鼠脑组织脂褐质(LF)升高,血清和脑组织中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性下降,一氧化氮(NO)和丙二醛(MDA)含量增加.分别给予15,30 mg/kg白藜芦醇灌胃后能使衰老模型小鼠脑组织和血清中NO、MDA不同程度下降,SOD及GSH-Px活性不同程度升高,脑组织中LF降低.结论白藜芦醇可通过清除氧自由基及抗脂质过氧化而抗衰老.

Effect of Resveratrol on Oxidative Damage Induced by D-galactose in Senile Mice

Objective To investigate the neutralization effect of resveratrol on oxidative damage induced by D-galactose in aged mice.Methods The senile model mice,were established by subcutaneous injection of 5% D-galactose at the nape,and adminstrated with resveratrol(15, 30 mg/kg) by oral gavage for 30 d.The lipofuscin(LF) and nitric oxide(NO) contents in brain,malondialdehyde(MDA) level,superoxide dismutase(SOD) and GSH-Px activities in serum and brain were detected by biochemistry method.Results In serum and brain of senile mice,the contents of NO and MDA increased,the activities of SOD and GSH-Px decrease.In addition,the LF in brain also elevated.Resveratrol administration of 15,30 mg/kg showed different degrees of antagonistic effect on the increase of MDA and NO levels,elevated the SOD and GSH-Px activities in serum and brain,decrease LF level in brain.Conclusion Resveratrol may postpone senility by eliminating oxygen free radicals and antilipoperoxidation.