何首乌、制何首乌对大鼠免疫球蛋白影响的实验研究

[目的]研究何首乌、制何首乌对SD大鼠免疫球蛋白的影响.[方法]将大鼠分为7组,每日灌胃主药30g/kg,连续给药90d,测定大鼠血清中免疫球蛋白G(IgG)、IgM、IgA的含量和胸腺质量.[结果]给药组与对照组比较,给药60d时大鼠血清中IgM含量,何首乌组、何首乌配大剂量茯苓组、何首乌配小剂量茯苓组、制首乌组、制何首乌配小剂量茯苓组均呈显著性升高(P<0.05).给药90 d时何首乌配大剂量茯苓组、何首乌配小剂量茯苓组、制何首乌配大剂量茯苓组呈显著性升高(P<0.05).lgG含量仅给药90 d的何首乌配小剂量茯苓组降低,以上各组均具有统计学意义.[结论]给药60d、90d何首乌、制何首乌各给药组可以显著增加大鼠血清中IgM的含量,有可能对肝脏的损伤造成有一定意义的影响.

Effect of polygonum multiflorum and polygonum multiflorum preparation on immunoglobulin in rats

[Objective] To research the influence of polygonum multi.florum and polygonum multiflorum preparation on immunoglobulin in SD rats. [Methods] SD rats were divided into seven groups. Each group was administrated with drug,30g/kg a day orally for 90 d. The blood samples were taken on the 90 d for determination of serum IgG,IgM levels. [Results] Comparing control group and experimental groups after 60 d administration of polygonum multiflorum,polygonum multiflorum with high-dose hoelen group,polygonum mul-tiflorum with low-dose hoelen group,preparation polygoni multiflori,preparation polygoni multiflori with low-dose hoelen group the serum IgM levels were significantly elevated(P<0.05),while the level after 90 d administration of polygonum multiflorum with high-dose hoelen group,polygonum multiflorum with low-dose hoelen group,preparation polygoni multiflori with high-dose hoelen group was significantly increased (P<0. 05),the level of serum IgG,however,in group of polygonum multiflorum with low-dose hoelen group only after the 90 d administration was reduced. Between these groups they were statistically significant. [Conclusion] Administration of the polygonum multiflorum,preparation of polygonum multiflorum system for 60 or 90 d can induce a significant increase of serum IgM in rats,that can cause some liver damage.