| Bcl—2和bax蛋白在大鼠脑缺血处理脑组织中的表达 |
| |
| 引用本文： | 王锷,郭曲练,等.Bcl—2和bax蛋白在大鼠脑缺血处理脑组织中的表达[J].湖南医科大学学报,2001,26(3):217-218. |
| |
| 作者姓名： | 王锷 郭曲练 |
| |
| 摘 要： | 目的：探讨凋亡相关基因Bcl-2和bax蛋白在脑缺血预处理过程中的表达及意义。方法：用免疫组织化学SP法分别对假手术对照组、缺血预处理对照组、缺血组和缺血预处理组大鼠前脑组织冰冻切片进行检测。结果：缺血预处理对照组Bcl-2蛋白的表达高于其他3组，而各组bax蛋白表达差异不显著。结论：缺血预处理时bcl-2蛋白表达的诱导可能是缺血预处理产生抗损伤保护性机制的原因之一。
|
| 关 键 词： | 脑缺血 预处理 免疫组织化学 大鼠 Bcl－2蛋白 bax蛋白 |
Bcl-2 and bax expression in rat cerebral ischemic preconditioning] |
| |
| E Wang,Q L Guo,X J Tan.Bcl-2 and bax expression in rat cerebral ischemic preconditioning][J].Bulletin of Hunan Medical University,2001,26(3):217-218. |
| |
| Authors: | E Wang Q L Guo X J Tan |
| |
| Institution: | Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China. |
| |
| Abstract: | OBJECTIVE: To study the expression of apoptosis regulated genes bcl-2 and bax nocoprotein expression and its significance in rat cerebral ischemic preconditioning. METHODS: With immunohistochemical assay, bcl-2 and bax expression were studied in rat brains which were divided into four groups: the sham-operation control group, the cerebral ischemic group and the cerebral ischemic preconditioning group. RESULTS: Bcl-2 oncoprotein was induced in cerebral ischemic preconditioning control group. Bax oncoprotein expression had no obviously difference in four groups. CONCLUSIONS: The expression of bcl-2 and bax oncoprotein after sublethal ischemic preconditioning might be associated with the preconditioning protection against neuronal damage following subsequent lethal ischemia. |
| |
| Keywords: | |
| 本文献已被 维普 等数据库收录！ |
