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针刺对快速老化脑萎缩模型小鼠脑抗氧化酶活性的影响
引用本文:刘一凡,石学敏,韩景献,王舒,李平,刘庆忠,赵立荣,杨增瑞,赵俊红,李晓康. 针刺对快速老化脑萎缩模型小鼠脑抗氧化酶活性的影响[J]. 中国针灸, 2002, 22(5): 13-21
作者姓名:刘一凡  石学敏  韩景献  王舒  李平  刘庆忠  赵立荣  杨增瑞  赵俊红  李晓康
作者单位:1. 山东中医药大学,济南,250014
2. 天津中医学院第一附属医院
基金项目:天津市自然科学基金资助项目课题号 (973 60 92 11)
摘    要:目的:观察针刺“水沟”,“内关”,“太冲”穴对快速老化脑萎缩模型小鼠(SAM-P/10)脑丙二醛含量(MDA),超氧化物歧化酶(SOD),过氧化氢酶(CAT),谷胱甘肽过氧化物酶(GSH-Px)活性的影响,结果:针刺可降低模型动物MDA含量,提高抗氧化酶活性,结论:抗氧化酶活性降低可能是脑老化的重要因素,针刺可从整个抗氧化体系水平提高机体抗氧化能力,减少自由基代谢产物,从而起到延缓脑老化的作用。

关 键 词:快速老化脑萎缩 小鼠 脑 抗氧化酶活性 衰老 针灸效应
文章编号:0255-2930(2002)05-0327-04
修稿时间:2001-02-13

Effect of Acupuncture on Activity of Antioxydase in the of the Brain Senescence Accelerated En- cephalatrophy Model Mouse
Liu Yifan ,Shi Xuemin ,Han Jingxian ,et al.. Effect of Acupuncture on Activity of Antioxydase in the of the Brain Senescence Accelerated En- cephalatrophy Model Mouse[J]. Chinese acupuncture & moxibustion, 2002, 22(5): 13-21
Authors:Liu Yifan   Shi Xuemin   Han Jingxian   et al.
Affiliation:Liu Yifan 1,Shi Xuemin 2,Han Jingxian 2,et al.
Abstract:purpose To observe effects of acupuncture at "Shuigou"(GV 26), "Neiguan" (PC 6), "Taichong" (LR 3) on content of malondialdehyde (MDA) and activities of superoxide dismutase (SOD) and catalase (CAT) and glutathione reductase (GSH Px) in the brain of the senescence accelerated encephalatrophy model mouse (SAM P/10). Results Acupuncture decreased the MDA content and increased the activity of antioxydase. Conclusions The decrease of antioxydase activity is possibly an imortant factor of aging, and acupuncture can increase antioxydative capability and reduce metabolites of free radicals, so as to exert the action of postponing brain aging.
Keywords:Aging/acup eff  Brain/enzymol  Atrophy/enzymol  Superoxide Dismutase/metab  Malondialdehyde/anal
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