平阳霉素注射治疗婴幼儿眼部血管瘤的临床效果

目的探索应用平阳霉素注射治疗婴幼儿眼部不同部位、各种类型血管瘤的效果.方法将平阳霉素均匀注射至血管瘤瘤体内,以注射至瘤体部位泛白为止.共治疗眼部血管瘤患儿45例,其中女23例,男22例.结果注射后瘤体肿胀,8例瘤体表面皮肤发生坏死,经过注射的瘤体组织由红色转为白色,并且变硬.2～3个月后变软,吸收、治愈.45例中,43例（占95.5%）经过2～5次注射后血管瘤完全消失,1例效果欠佳,改用其他方法治疗,另1例毛细血管瘤用其他治疗方法有效,但效果不明显,在加用注射平阳霉素后彻底治愈.结论应用平阳霉素治疗婴幼儿几类眼部血管瘤,绝大部分效果显著,并具有损害小、瘢痕轻、外观效果较好等特点.

Clinical efficacy of bleomycinum A5 in treatment of infant hemangioma in eye

Objective To investigate the clinical efficacy of bleomycinum A5 on different type and site of eye hemangioma in infant. Methods 45 infant cases (23 females and 22 males) of hemangioma of eye were studied from the outpatient deparment of our hospital between 1996 and 2001. The powder of bleomycinum A5 was dissolved in 2 % procaine solution. The mixed liquid was injected uniformly into the mass of hemangioma of eye until it appeared offwhite.Results After the injection, the masses of hemangioma of eye swelled and atrophied subsequently, and the reaction disappeared within 7 days. The appearance of the local tissue turned from red to white. The hardness of it became soft several months after injection. 43 of 45 (95.5 %) patients healed after 2~5 times injection. Conclusions This method is proved effective to different type of hemangioma in infant eye, with minor damage, mild scar formation and good appearance. The side effect includes delay of development in the socket of orbit bone, local tissue necrosis and pigmentation of the skin.