Platelet-activating factor receptor (PAF-R)-dependent pathways control tumour growth and tumour response to chemotherapy |
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| Authors: | Soraya I de Oliveira Luciana NS Andrade Ana C Onuchic Sueli Nonogaki Patrícia D Fernandes Mônica C Pinheiro Ciro BS Rohde Roger Chammas Sonia Jancar |
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| Affiliation: | (1) Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil;(2) Department of Radiology, University of Sao Paulo Medical School, University of Sao Paulo, Sao Paulo, Brazil;(3) Department of Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;(4) Adolfo Lutz Institute, Sao Paulo, Brazil |
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| Abstract: | Background Phagocytosis of apoptotic cells by macrophages induces a suppressor phenotype. Previous data from our group suggested that this occurs via Platelet-activating factor receptor (PAF-R)-mediated pathways. In the present study, we investigated the impact of apoptotic cell inoculation or induction by a chemotherapeutic agent (dacarbazine, DTIC) on tumour growth, microenvironmental parameters and survival, and the effect of treatment with a PAF-R antagonist (WEB2170). These studies were performed in murine tumours: Ehrlich Ascitis Tumour (EAT) and B16F10 melanoma. |
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