| 甲酰四氢叶酸钙解救大剂量甲氨蝶呤化疗致急性胃肠道黏膜损伤13例效果研究 |
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| 引用本文： | 朱梅,裴忠利,张秀萍. 甲酰四氢叶酸钙解救大剂量甲氨蝶呤化疗致急性胃肠道黏膜损伤13例效果研究[J]. 齐鲁护理杂志, 2011, 17(13): 19-21 |
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| 作者姓名： | 朱梅 裴忠利 张秀萍 |
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| 作者单位： | 滕州市中心人民医院,山东,滕州,277500 |
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| 摘 要： | 目的:探讨甲酰四氢叶酸钙(CF)解救大剂量甲氨蝶呤(HDMTX)化疗致急性淋巴细胞白血病(ALL)患儿胃肠道黏膜损伤的效果。方法:将25例患儿随机分为观察组13例和对照组12例,两组化疗总量、疗程、准备工作等相同,观察组在12 h静脉滴注完甲氨蝶呤(MTX)后第12小时使用CF解救,对照组在6.5 h静脉滴注完MTX后第29.5小时使用CF解救。观察两组患儿恶心和呕吐程度、口腔黏膜反应程度、反应持续时间。结果:两组患儿化疗后胃肠道反应程度、口腔黏膜反应程度、反应持续时间比较差异均有统计学意义(P<0.01)。结论:24 h静脉滴注MTX后第12小时开始给予CF解救更有利于保护胃肠道和口腔黏膜,促进受损组织细胞修复,提高化疗效果和患儿生存质量,具有较好的临床应用价值。
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| 关 键 词： | 甲酰四氢叶酸钙 大剂量 甲氨蝶呤 化疗 毒性 解救 |
Research on the effect of Calcium Folinate on rescuing 13 cases of acute gastrointestinal mucosal injury induced by chemotherapy with high-dose Methotrexate |
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| Zhu Mei,Pei Zhong-li,Zhang Xiu-ping. Research on the effect of Calcium Folinate on rescuing 13 cases of acute gastrointestinal mucosal injury induced by chemotherapy with high-dose Methotrexate[J]. Journal of Qilu Nursing, 2011, 17(13): 19-21 |
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| Authors: | Zhu Mei Pei Zhong-li Zhang Xiu-ping |
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| Affiliation: | Zhu Mei,Pei Zhong-li,Zhang Xiu-ping (Central People's Hospital of Tengzhou Municipality,Tengzhou Shandong 277500,China) |
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| Abstract: | Objective: To explore the effect of Calcium Folinate(CF) on rescuing acute gastrointestinal mucosal injury induced by chemotherapy with high-dose Methotrexate(MTX) in the children patients with acute lymphoblastic leukemia(ALL).Methods: 25 children patients were randomly divided into observation group(n=13) and control group(n=12).The dose of chemotherapy,courses of treatment and preparation were the same in the two groups.In the observation group,CF was used in the 12th hour to rescue the children patients... |
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| Keywords: | CF High dose MTX Chemotherapy Toxicity Rescue |
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