| TRAIL联合药物诱导肿瘤细胞凋亡协同机制的研究 |
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| 引用本文： | 李雪燕,杜晶春,徐霞. TRAIL联合药物诱导肿瘤细胞凋亡协同机制的研究[J]. 分子诊断与治疗杂志, 2012, 4(3): 206-211 |
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| 作者姓名： | 李雪燕 杜晶春 徐霞 |
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| 作者单位： | 广州医学院检验系,广东,广州,510182 |
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| 基金项目： | 国家自然科学基金，第三轮广州市属高校重点学科建设经费资助 |
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| 摘 要： | 肿瘤坏死因子相关的凋亡诱导配体（tumor necrosis factor-related apoptosis inducingligand，TRAIL）能选择性诱导肿瘤细胞和恶性转化细胞凋亡，对大多数正常细胞却无杀伤作用，被认为是一种非常具有发展潜力的抗肿瘤因子，近年已成为国内外研究的热点。许多学者发现在TRAIL联合各种药物作用于肿瘤细胞的过程中二者有协同效应，但不同药物与TRAIL协同诱导肿瘤细胞凋亡的机制各不相同。
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| 关 键 词： | 肿瘤坏死因子相关的凋亡诱导配体（TRAIL） 凋亡 协同效应 机制 |
Research on the synergistic mechanism of TRAIL combined drugs induce tumor cells apoptosis |
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| Li Xueyan , Du Jingchun , XU Xia. Research on the synergistic mechanism of TRAIL combined drugs induce tumor cells apoptosis[J]. Journal of Molecular Diagnosis and Therapy, 2012, 4(3): 206-211 |
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| Authors: | Li Xueyan Du Jingchun XU Xia |
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| Affiliation: | (The Faculty of Laboratory Medicine, Guangzhou Medical College, Guangdong, Guangzhou 510182, China) |
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| Abstract: | Tumor necrosis factor-related apoptosis inducing ligand （TRAIL） is a member of the TNF family of cytokines and has been shown to induce cell apoptosis in many types of tumor cells and malignant transformation cells, but not in normal cells. It is thought to be a very potential antitumor factor and has become a hot research spot. Many researchers found that a combination of TRAIL and chemotherapeutics bears a synergistic effect, but the mechanism is not fully defined. |
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| Keywords: | Tumor necrosis factor-related apoptosis inducing ligand（TRAIL） Apoptosis Synergistic effect Mechanism |
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