| 抑癌因子DNA高甲基化与肿瘤 |
| |
| 引用本文： | 刘琴,杨惠玲.抑癌因子DNA高甲基化与肿瘤[J].分子诊断与治疗杂志,2012,4(3):145-152. |
| |
| 作者姓名： | 刘琴 杨惠玲 |
| |
| 作者单位： | 中山大学中山医学院病理生理学教研室,广东,广州510080 |
| |
| 基金项目： | 国家自然科学基金，广东省自然科学基金，广东省科技计划 |
| |
| 摘 要： | 肿瘤DNA甲基化的异常包括基因组整体甲基化水平降低或和某些基因启动子区域甲基化水平异常升高。前者可导致原癌基因活化及基因组不稳定等，而基因启动子区域发生异常高甲基化则可导致基因转录沉默，使重要基因如抑癌基因等低表达或不表达及增加点突变，并通过影响多条细胞信号转导通路来干预细胞周期和细胞凋亡等，从而影响肿瘤的发生发展及预后和治疗。了解抑癌因子DNA高甲基化与肿瘤的研究现状，可望为揭示肿瘤发生机制提供新的思路，为肿瘤诊断和治疗提供新的标记物和靶点。
|
| 关 键 词： | 抑癌基因 DNA甲基化 肿瘤 分子标记物 治疗靶点 |
DNA hypermethylation of tumour suppressor gene and cancer |
| |
| Liu Qin
,
Yang Huiling.DNA hypermethylation of tumour suppressor gene and cancer[J].Journal of Molecular Diagnosis and Therapy,2012,4(3):145-152. |
| |
| Authors: | Liu Qin Yang Huiling |
| |
| Institution: | (Zhongshan School of Medicine, Sun Yat-sen University, Guangdong, Guangzhou 510080, China) |
| |
| Abstract: | The unbalanced DNA methylation in cancer includes global hypomethylation and promoter hypermethylation. The global hypomethylation of cancer cell genomes results in oncogene activation and chromosomal instability, and aberrant promoter hypermethylation is associated with inappropriate gene silencing. The methylation changes influence the cell proliferation and apoptosis, which affects virtually every step in cancer progression by cell signaling pathways. And it offer new insight into the diagnosis and treatment of the cancer and provide the novel biomarker and therapeutic targets. |
| |
| Keywords: | Tumour suppressor gene DNA methylation Cancer biomarker Therapeutic target |
| 本文献已被 维普 万方数据 等数据库收录！ |
