乳腺浸润性导管/小叶混合癌与浸润性小叶癌、导管癌的临床病理特征及预后差异

目的 研究乳腺浸润性导管/小叶混合癌(infiltrative ductal/lobular mixed carcinoma,IDC-L)与浸润性小叶癌(infiltrative lobular carcinoma,ILC)及浸润性导管癌(infiltrative ductal carcinoma,IDC)病理特征及预...

Clinicopathological characteristics and prognosis of invasive ductal/lobular mixed carcinoma,invasive lobular carcinoma and invasive ductal carcinoma of breast

Objective To study the pathological characteristics of breast infiltrative ductal/lobular mixed carcinoma(IDC-L),infiltrative lobular carcinoma(ILC)and infiltrative ductal carcinoma(IDC).Methods From September 2011 to September 2020,254 breast cancer patients were selected,Among them,there were 18 cases of IDC-L,20 cases of ILC and 216 cases of IDC.The prognosis of the three groups of patients was observed.Results IDC-L,ILC and IDC patients had significant differences in age,tumor size,multicentric lesions,vascular invasion,HER2 status,Ki-67 expression.IDC-L patients had younger onset age,more tumor diameter>2.0 cm,while IDC patients had less multicentric lesions and vascular invasion,while HER2 positive rate and Ki-67 high expression ratio in IDC-L and ILC patients were lower than IDC,the difference was statistically significant(P<0.05).Age,climacteric state,tumor size,lymph node state,multicentric lesions,lymphatic vessel invasion,HER2 state and Ki-67 expression were all the influencing factors of clinic pathological differences.Breast cancer-free interval and overall survival were related to tumor size,lymph node status,lymphatic vessel invasion and Ki-67 expression(P<0.05).Conclusion In breast cancer patients,the clinicopathological characteristics of ILC and IDC-L are similar to each other,but there are obvious differences among ILC,IDC-L and IDC.The breast cancer patients can be differentiated clinically and treated better.