Intense and exhaustive exercise induce oxidative stress in skeletal muscle |
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| Authors: | T Thirumalai S Viviyan Therasa EK Elumalai E David |
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| Affiliation: | 1. Heart and Vascular Center, Semmelweis University, Városmajor u. 68, 1122 Budapest, Hungary;2. Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, T?zoltó u. 37-47, 1094 Budapest, Hungary;3. Department of Cardiac Surgery, University of Heidelberg, 2. OG. INF 326, 69120 Heidelberg, Germany;1. School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil;2. Vascular Biology Laboratory, Heart Institute, University of Sao Paulo, Brazil;1. Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Centro Integrado de Pós-Graduação e Pesquisa em Saúde – CIPq-Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Campus JK, Alto da Jacuba, Minas Gerais, Brazil;2. Núcleo de Neurociências (NNC), Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, Brazil;3. Faculty of Motor Sciences, Université of Libre de Bruxelles, Belgium;4. Faculty of Physical Education and Physiotherapy Department of Human Physiology and Sportsmedicine, Vrije Universiteit Brussel, Belgium |
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| Abstract: | ObjectiveTo assess the oxidative stress and antioxidant defense system in the skeletal muscle of male albino rats subjected to strenuous exercise programme.MethodsWistar strain albino rats were subjected to exhaustive swimming exercise programme daily for a period of five days. The thiobarbituric acid reactive substances (TBARS), conjugated dienes, superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase were measured in the gastrocnemius muscle of the exercised animals.ResultsThe elevated levels of TBARS and conjugated dienes indicated the oxidative stress in the gastrocemius muscle of the exercised animals. The depleted activity levels of superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase in the exercise animals indicated the increased oxidative stress and decreased antioxidative defense system in the muscle.ConclusionsThe study suggests that prolonged strenuous exercise programme can induce oxidative stress and therefore an optimal level of exercise schedule should be advocated to obtain the maximum benefit of exercise programme. |
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