急性ST段抬高型心肌梗死患者PCI术后血清分泌型卷曲相关蛋白5水平及预后

目的探讨急性ST段抬高型心肌梗死(ASTEMI)患者经皮冠状动脉介入治疗(PCI)术后血清分泌型卷曲相关蛋白(SFRP)5水平及其与预后的关系。方法选取2016年9月至2018年9月阜阳市人民医院收治的219例拟行PCI术ASTEMI患者作为研究对象。采用酶联免疫吸附试验检测ASTEMI患者血清SFRP5水平,分析其与预后的关系。结果PCI术后6个月共有27例(12.3%)ASTEMI患者预后不良。预后不良组患者血清SFRP5水平低于预后良好组,差异有统计学意义(t=6.749,P<0.05)。Logistic多因素回归分析显示,冠状动脉病变支数、NYHA分级、SFRP5与ASTEMI患者PCI术后预后不良密切相关(P<0.05)。模型B评估ASTEMI患者PCI术后预后的效能高于SFRP5和模型A,差异均有显著统计学意义(P<0.01)。结论ASTEMI患者PCI术后血清SFRP5水平与患者预后密切相关。血清SFRP5水平检测有助于评估患者预后。

Serum level of SFRP5 in patients with acute ST-segment elevation myocardial infarction after PCI and its relationship with prognosis

Objective To investigate the serum level of secreted frizzled-related protein 5(SFRP5)in patients with acute ST-segment elevation myocardial infarction(ASTEMI)after percutaneous coronary intervention(PCI),and to analyze its relationship with prognosis.Methods A total of 219 ASTEMI patients,who were admitted to the Fuyang Municipal People’s Hospital of China during the period from September 2016 to September 2018 and were scheduled to receive PCI,were enrolled in this study.Enzyme linked immunosorbent assay(ELISA)was used to test the serum level of SFRP5 in patients with ASTEMI,and the correlation between the level of SFRP5 and patient’s prognosis was analyzed.Results A total of 27 ASTEMI patients(12.33%)showed a poor prognosis at 6 months after PCI(poor prognosis group).The serum SFRP5 level in the poor prognosis group was lower than that in the good prognosis group,and the difference was statistically significant(t=6.749,P<0.05).Logistic regression analysis showed that the number of diseased coronary branches,NYHA classification and serum SFRP5 level were closely related to the poor prognosis of ASTEMI patients after PCI(P<0.05).In evaluating the prognosis of ASTEMI patients after PCI,the efficacy of model B was higher than that of serum SFRP5 level as well as that of model A,and the difference was statistically significant(P<0.01 in both).Conclusion Serum SFRP5 level in ASTEMI patients after PCI is closely related to the prognosis of patients.The testing of serum SFRP5 level is helpful for the evaluation of the prognosis of ASTEMI patients.