Audiological and genetics studies in high-risk infants |
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| Authors: | Maria Francisca Colella-Santos Maria de Fátima de Campos Françozo Christiane Marques do Couto Maria Cecilia Marconi Pinheiro Lima Tatiana Guilhermino Tazinazzio Arthur Menino Castilho Edi Lucia Sartorato |
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| Institution: | 1. Doctoral degree, assistant professor and coordinator of the Speech Therapy Course, Medical School, UNICAMP;2. Doctoral degree, assistant professor of the Speech Therapy Course, Medical School, UNICAMP;3. Doctoral degree, assistant professor of the Speech Therapy Course, Medical School, UNICAMP;4. Doctoral degree, assistant professor of the Speech Therapy Course, Medical School, UNICAMP;5. Master''s degree, speech therapist of the Neonatology Unit, Prof. Dr. José Aristodemo Pinotti Women''s Hospital (CAISM);6. Doctoral degree, otorhinolaryngologist of the Ophthalmology/Otorhinolaryngology Department, Medical School, UNICAMP;7. Doctoral degree, researcher of the Genetics and Molecular Biology Center (Centro de Biologia Molecular e Genética), UNICAMP |
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| Abstract: | Hearing is one of the main ways with which one person can contact the external world; it plays a key role in their integration with society.AimThe objective of this study was to analyze the results of the hearing, medical and genetic evaluation of high-risk infants who failed the newborn hearing screening.Materials and MethodsClinical and experimental study. We assessed thirty-eight neonates, with ages between one and six months. The infants underwent the following procedures: medical interview; immittance testing; Brainstem Auditory Evoked Potential; Transient Evoked Otoacoustic Emission and otorhinolaryngological evaluation. DNA extraction from the oral mucosa was performed for genetic studies using the protocol method adapted from the Human Genetics Lab of the CBMEG/UNICAMP.ResultsRegarding gender and presence of risk factors, significant statistically differences were not found in normal hearing infants and in those with hearing loss. Concerning gestational age, term infants were more affected by hearing loss. Hearing loss was identified in 58% of the sample, conduction hearing loss represented 31.5% (12/38) and neurossensory 28.9% of cases. There were none of the genetic mutations most commonly seen in cases with a genetic etiology.ConclusionHearing loss was identified in the majority of High-risk infants. |
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| Keywords: | child hearing hearing loss hearing tests |
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