胃癌患者CyPJ、ERp29及CSN5的表达其与预后生存的关系研究

目的分析胃癌患者亲环素J(CyPJ)、内质网蛋白质29(ERp29)及CSN5的表达其与预后生存的关系。方法纳入2015年6月至2017年6月本院收治的115例胃癌患者肿瘤组织(癌组织组)及肿瘤旁的正常胃粘膜组织(癌旁正常组织组)。比较CyPJ、ERp29及CSN5在不同组织中的表达;分析CyPJ、ERp29及CSN5与胃癌患者各病理参数的相关性,以Kaplan-Meier生存分析CyPJ、ERp29及CSN5表达对胃癌患者预后生存的影响;采用多元Logistic回归分析影响胃癌患者预后生存的危险因素。结果胃癌组织组CyPJ、CSN5阳性表达率显著高于癌旁正常组织,ERp29较癌旁正常组织阳性表达率低,差异均有统计学意义(P<0.05);年龄、性别、浆膜浸润与胃癌患者CyPJ、ERp29及CSN5表达无相关(P>0.05)。临床分期、浸润深度、淋巴结转移与患者CyPJ、CSN5表达呈正相关,组织分化程度与CyPJ、CSN5表达呈负相关(P<0.05)。ERp29与组织分化程度呈正相关,与临床分期、浸润深度、淋巴结转移呈负相关(P<0.05)。截至随访结束,115例胃癌患者生存79例,死亡36例,死亡率为31.30%;生存分析显示CyPJ及CSN5(表达阴性)、ERp29(表达阳性)者生存期较长,Keplan-meier生存曲线明显不同(P<0.05)。组织中低分化、TNM分期:Ⅲ+Ⅳ期、淋巴结转移、ERp29阴性表达、CyPJ及CSN5阳性表达为影响胃癌患者预后生存的独立危险因素(P<0.05)。结论 CyPJ、ERp29及CSN5在胃癌组织中呈异常表达状态;其表达水平与患者的肿瘤临床病理特征及预后有关。

Study on the relationship between the expressions of CyPJ,ERp29 and CSN5 in patients with gastric cancer and prognostic survival

Objective To analyze the relationship between the expression of CyPJ,ERp29 and CSN5 in patients with gastric cancer and the prognosis and survival. Method The data of 115 patients with gastric cancer admitted to our hospital from June 2015 to June 2017 were retrospectively analyzed,and tumor tissue(cancer tissue group)and normal gastric mucosal tissue adjacent to the tumor(paracancerous normaltissue group)were collected. The expressions of CyPJ,ERp29 and CSN5 in different tissues were compared. The correlation between CyPJ,ERp29 and CSN5 and the pathological parameters of patients with gastric cancer was analyzed. Kaplan-Meier survival analysis was used to analyze the effect of CyPJ,ERp29 and CSN5 expression on the prognosis survival of patients with gastric cancer and multivariate Logistic regression was used to analyze the risk factors affecting the prognosis and survival. Result The positive expression rates of CyPJ and CSN5 in the gastric cancer tissue group were significantly higher than those in the paracancerous normal tissue group,and the positive expression rate of ERp29 was lower than that in the paracancerous normal tissue group. The difference was statistically significant(P<0.05). There was no significant correlation between age,gender,serosal-infiltration and the expression of CyPJ,ERp29 and CSN5 in gastric cancer patients(P>0.05),but the clinical stage,depth of invasion,and lymph node metastasis were positively correlated with the expression of CyPJ and CSN5,and the degree of tissue differentiation was negatively correlated with the expression of CyPJ and CSN5.ERp29 was positively correlated with the degree of tissue differentiation,and negatively correlated with clinical stage,depth of invasion,and lymph node metastasis(P<0.05). At the end of the follow-up,79 patients with gastric cancer survived,36 died,and the mortality rate was 31.30%. Survival analysis showed that patients with CyPJ,CSN5(expression negative)and ERp29(expression positive)had longer survival times,and Keplanmeier survival curves were significantly different(P<0.05). Moderate to low differentiation of tissues,TNM staging:stage Ⅲ+Ⅳ,lymph node metastasis,negative expression of ERp29,positive expression of CyPJ and CSN5 were independent risk factors affecting the prognosis and survival of patients with gastric cancer(P<0.05). Conclusion CyPJ,ERp29 and CSN5 are abnormally expressed in gastric cancer tissues. Their expression levels are related to the clinicopathological characteristics and prognosis of the tumor.