| 芦丁神经保护作用的研究现状 |
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| 引用本文： | 韩晶晶,吴俊丽,张峰. 芦丁神经保护作用的研究现状[J]. 中国临床药理学杂志, 2021, 0(7): 922-924 |
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| 作者姓名： | 韩晶晶 吴俊丽 张峰 |
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| 作者单位： | 河南大学药学院 |
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| 基金项目： | 国家自然科学基金资助项目(31800287);河南省教育厅科学技术研究重点项目基金资助项目(19B360001);河南大学科学研究基金资助项目(2012YBZR035)。 |
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| 摘 要： | 芦丁是广泛存在于植物中的黄酮醇配体,具有抗氧化、抗炎、降压、维持血管弹性和神经保护等多种药理活性,在心脑血管疾病的治疗与预防起到至关重要的作用,有望可以改善或预防脑血管病、神经退行性病变及其他神经系统疾病.本文根据近年来的体内、外实验研究结果,综述了芦丁在缺血性脑卒中、阿尔茨海默病、帕金森病、抗癫痫和抗抑郁发挥脑神经保...
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| 关 键 词： | 芦丁 神经保护作用 缺血性脑卒中 阿尔茨海默病 帕金森病 |
Research status on the neuroprotective effect of rutin |
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| HAN Jing-jing,WU Jun-li,ZHANG Feng. Research status on the neuroprotective effect of rutin[J]. The Chinese Journal of Clinical Pharmacology, 2021, 0(7): 922-924 |
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| Authors: | HAN Jing-jing WU Jun-li ZHANG Feng |
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| Affiliation: | (College of Pharmacy,Henan University,Kaifeng 475004,Henan Province,China) |
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| Abstract: | Rutin is a flavonol ligand widely found in plants,which has a variety of pharmacological activities,such as anti-oxidation,anti-inflammation,antihypertensive,maintenance of vascular elasticity and neuroprotection,and plays an important role in the treatment and prevention of cardiovascular and cerebrovascular diseases.It is expected to improve or prevent cerebrovascular diseases,neurodegenerative diseases and other nervous system diseases.Based on the results of in vivo and in vitro experimental studies in recent years,this paper reviews the neuroprotective mechanism of rutin in ischemic stroke,Alzheimer’s disease,Parkinson’s disease,antiepileptic and antidepressant. |
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| Keywords: | Rutin neuroprotection ischemic stroke Alzheimer’s disease Parkinson’s disease |
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