Study of patients with cleft lip and palate with consanguineous parents |
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Authors: | Sibele Nascimento de Aquino Lívia Máris Ribeiro Paranaíba Daniella Reis Barbosa Martelli Mário Sérgio Oliveira Swerts Letízia Monteiro de Barros Paulo Rogério Ferreti Bonan Hercílio Martelli Júnior |
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Affiliation: | 1. Graduate student in stomatopathology, Campinas State University (Universidade Estadual de Campinas) - Unicamp;2. Doctoral student of stomatopathology, Campinas State University - Unicamp;3. Professor of semiology, Montes Claros State University (Universidade Estadual de Montes Claros) - Unimontes;4. Professor at the Alfenas University (Universidade de Alfenas) - Unifenas;5. Professor at the Alfenas University (Universidade de Alfenas) - Unifenas;6. Professor at the Montes Claros State University - Unimontes;7. Doctoral degree, full professor, Montes Claros State University - Unimontes |
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Abstract: | Cleft lip and/or palate (CL/P) are the most common congenital anomalies of the face. CL/P are non-syndromic (CL/PNS) in about 70% of subjects.Aim: To describe clinical cases of non-syndromic CL/P (CL/PNS) associated with consanguinity, diagnosed at a reference hospital in Minas Gerais, Brazil, and to correlate these alterations with possible risk factors.Series and Methods: A retrospective study at a reference hospital for craniofacial deformities in Minas Gerais, Brazil from 2006 to 2009 based on data in medical records.Results: Of 246 CL/PNS cases diagnosed and treated at the institution, 15 (6.1%) were CL/PNS with reported first-degree consanguinity; 73.3% occurred in males. Four of 15 patients had complete right cleft palate and lip (CLP), 4 presented complete cleft palate and lip (right and left), 3 had complete unilateral left CLP, 3 had isolated cleft palate, and 1 presented cleft lip only. Among the risk factors, only three mothers reported smoking during pregnancy.Conclusions: CLP (unilateral or bilateral) were more frequent in the group with a history of first-degree consanguinity; males predominated. Among the risk factors, only smoking was observed in three cases. |
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Keywords: | consanguinity cleft lip cleft palate |
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