血清SAA、sTREM-1、PCT联合检测在新生儿宫内感染性肺炎中的价值

目的分析血清淀粉酶样蛋白A(SAA)、可溶性髓系细胞触发受体1(sTREM-1)、降钙素原(PCT)联合检测在新生儿宫内感染性肺炎早期诊断中的应用价值。方法选取本院118例新生儿,其中无宫内感染高危因素+未发生感染32例(对照组),有宫内感染高危因素+未发生感染40例(A组),有宫内感染高危因素+宫内感染性肺炎46例(B组),检测各组脐血SAA、sTREM-1、PCT水平,以受试者工作特征(ROC)曲线分析SAA、sTREM-1、PCT联合检测诊断价值。结果 B组SAA、sTREM-1、PCT水平明显高于对照组与A组,差异具有统计学意义(P<0.05)。对照组与A组SAA、sTREM-1、PCT水平比较差异无统计学意义(P>0.05)。ROC曲线分析显示,SAA诊断敏感度71.2%,特异度88.4%;sTREM-1诊断敏感度65.7%,特异度84.2%;PCT诊断敏感度72.6%,特异度90.3%;三者联合诊断敏感度85.7%,特异度94.5%。结论宫内感染性肺炎新生儿脐血SAA、sTREM-1及PCT表达水平呈明显升高趋势,三者联合对新生儿宫内感染性肺炎具有较高早期诊断价值。

Value of combined detection of serum SAA,sTREM-1 and PCT in neonatal intrauterine infectious pneumonia

Objective To analyze the application value of combined detection of serum amylase-like protein A(SAA),soluble triggering receptor expressed on myeloid cells 1(sTREM-1)and procalcitonin(PCT)in the early diagnosis of neonatal intrauterine infectious pneumonia. Methods A total of 118 neonates in the hospital were enrolled,including 32 cases without high risk factors of intrauterine infection and without infection(control group),40 cases with high risk factors of intrauterine infection and without infection(group A),and 46 cases with high risk factors of intrauterine infection and intrauterine infectious pneumonia(group B). The levels of cord blood SAA,sTREM-1 and PCT in each group were detected. The diagnostic value of combined detection of SAA,sTREM-1 and PCT was analyzed using the receiver operating characteristic(ROC)curves. Results The levels of SAA,sTREM-1 and PCT in group B were significantly higher than those in the control group and group A(P<0.05). There was no significant differencebetween the control group and the A group in the levels of SAA,sTREM-1 and PCT(P>0.05). ROC curve analysis showed that the diagnostic sensitivity and specificity of SAA,sTREM-1,PCT and the combination of the three were(71.2%,88.4%),(65.7%,84.2%),(72.6%,90.3%)and(85.7%,94.5%),respectively. Conclusion The expression levels of umbilical cord blood SAA,sTREM-1 and PCT in neonates with intrauterine pneumonia showed a significant increase,and the combination of the three has a high early diagnosis value for neonates with intrauterine pneumonia.