柴金汤加减治疗慢性胆囊炎肝胆湿热证临床疗效观察

目的:观察柴金汤加减治疗慢性胆囊炎肝胆湿热证的临床疗效。方法:将80例慢性胆囊炎肝胆湿热证患者,按入院的先后顺序随机分为试验组和对照组,每组40例。两组患者均给予常规治疗,试验组另给予柴金汤加减治疗,对照组另给予消炎利胆片治疗。结果:试验组治疗后中医证候积分、右上腹疼痛积分、压痛积分均低于对照组,差异有统计学意义(P<0.05);试验组治疗后胆囊壁厚度、胆囊容积低于对照组,胆囊排空率高于对照组,差异有统计学意义(P<0.05);试验组治疗后超氧化物歧化酶、白细胞介素-8水平高于对照组,肿瘤坏死因子-α、丙二醛水平低于对照组,差异有统计学意义(P<0.05);试验组有效率为92.5%,对照组有效率为80.0%,试验组高于对照组,差异有统计学意义(P<0.05)。结论:柴金汤加减治疗慢性胆囊炎肝胆湿热证,能促进胆汁排泄,减轻疼痛,增强胆囊功能,提高超氧化物歧化酶、白细胞介素-8水平,降低肿瘤坏死因子-α、丙二醛水平。

Clinical Effect Observation of Modified Chaijin Decoction in Treating Chronic Cholecystitis with Dampness-Heat Syndrome of Liver and Gallbladder

Objective:To observe the clinical curative effect of Modified Chaijin Decoction(柴金汤加减,MCJD)in treating chronic cholecystitis with dampness-heat syndrome of liver and gallbladder.Methods:A total of 80 patients with chronic cholecystitis were randomly divided into two groups:the experimental group and the control group,with 40 cases in each group according to the order of admission.The two groups were first given routine treatment,then the experimental group was additionally given MCJD,while the control group was additionally given Inflammation-Resolving Gall-Bladder-Excreting Tablets.Results:After the treatment,the TCM syndrome scores,right upper abdominal pain score and tenderness score of the experimental group were lower than those of the control group,and all the differences were statistically significant(P<0.05);the gallbladder wall thickness and gallbladder volume of the experimental group were lower than those of the control group,and the gallbladder emptying rate of the experimental group was higher than that of the control group,and all the differences were statistically significant(P<0.05);the levels of superoxide dismutase and interleukin-8 in the experimental group were higher than those in the control group,while the levels of tumor necrosis factor-αand malondialdehyde in the experimental group were lower than those in the control group,and all the differences were statistically significant(P<0.05);the effective rate of the experimental group was 92.5%,which was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:In terms of chronic cholecystitis with dampness-heat syndrome of liver and gallbladder,MCJD can promote bile excretion,relieve pain,enhance gallbladder function,increase the levels of superoxide dismutase and interleukin-8,and reduce the levels of tumor necrosis factor-αand malondialdehyde.