Hcy、NSE及IL-8水平变化与脑卒中患者神经功能恢复的关系研究

目的分析半胱氨酸(Hcy)、神经元特异性烯醇化酶(NSE)及白介素-8(IL-8)水平变化与脑卒中患者神经功能恢复的关系。方法选取2017年4月至2019年4月本科室收治的116例缺血性脑卒中急性期后康复患者作为研究组,根据急性期神经功能缺损程度,以及稳定期Brunnstrom分期和ADL指数另分为三个亚组:轻度依赖组46例,中度依赖组40例,重度依赖组30例。同时纳入同期本院健康体检正常者108例作为对照组。比较研究组与对照组Hcy、NSE及IL-8水平差异及Hcy、NSE及IL-8水平在神经功能缺损评分中的表达情况。绘制散点图,采用Pearson相关分析分别观察脑卒中患者Hcy、NSE及IL-8水平与神经功能评分的关系。结果研究组患者Hcy、NSE、IL-8水平显著高于对照组,差异具有统计学意义(P<0.05);不同神经缺损患者血清Hcy、NSE、IL-8水平:重度依赖组>中度依赖组>轻度依赖组,差异有统计学意义(P<0.05);脑卒中患者Hcy、NSE及IL-8与NIHSS评分呈正相关,与Brunnstrom分期和ADL指数呈负相关(P<0.05)。结论 Hcy、NSE及IL-8水平对脑卒中患者神经功能及康复指标具有重要意义,临床工作者可通过加强监测这三项指标,评估疾病进展与预后情况。

Relationship between the changes of Hcy,NSE and IL-8 levels and the recovery of neurological function in stroke patients

Objective To analyze the relationship between the changes of Hcy,NSE and IL-8 levels and the recovery of neurological function in stroke patients. Methods A total of 116 stroke patients recovered from acute ischemic stroke in this department from April 2017 to April 2019 were selected as the study group. According to the degree of neurological deficit in the acute phase,the Brunnstrom staging and ADL index in the stable phase,they were divided into three subgroup:46 cases in the mildly dependent group;40 cases in the moderately dependent group;and 30 cases in the severely dependent group. At the same time,108 patients with normal physical examination in this hospital were included as the control group. The differences in the levels of Hcy,NSE and IL-8 between the study group and the control group and the expression of Hcy,NSE and IL-8 levels in the neurological deficit score were compared. A scatter plot was drawn,and Pearson correlation analysis was used to observe the relationship between Hcy,NSE and IL-8 levels and neurological scores in stroke patients. Results he levels of Hcy,NSE and IL-8 in the study group were significantly higher than those in the control group and the difference was statistically significant(P<0.05). Serum Hcy,NSE,IL-8 levels in patients with different neurological deficits:severely dependent group > moderately dependent group > lightly dependent group and the difference was statistically significant(P<0.05). The levels of Hcy,NSE and IL-8 in patients with coronary stroke were positively correlated with NIHSS score,and negatively correlated with Brunnstrom staging and ADL index(P<0.05). Conclusion The serum levels of Hcy,NSE and IL-8 are of great significance to the neurological function and rehabilitation indicators of stroke patients.Clinicians can strengthen the monitoring of these three indicators to assess disease progression and prognosis.