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Assessment of frequency of micronucleated exfoliated buccal cells in relation to oxidative stress in oral lichen planus in coastal Karnataka,India
Authors:Madhurima Mukherjee  Prabin Gyawali  Rajesh Kumar Thakur  Revathi P Shenoy  Anjali Rao
Affiliation:1. Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI;2. Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA;3. Department of Urology, University of Iowa, Iowa City, IA;4. Department of Psychological and Brain Science, University of Iowa, Iowa City, IA;1. Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, No.155, Sec. 2, Linong St., Taipei, Taiwan;2. Institute of Biophotonics, National Yang-Ming University, No.155, Sec. 2, Linong St., Taipei, Taiwan;3. Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Taipei, Taiwan;4. School of Medicine, National Yang-Ming University, No.155, Sec. 2, Linong St., Taipei, Taiwan;5. Department of Radiology, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Taipei, Taiwan;6. Department of Neurology, Taipei Municipal Gan-Dau Hospital, No.12, Ln. 225, Zhixing Rd., Taipei, Taiwan
Abstract:ObjectiveTo assess the frequency of micronucleus in exfoliated buccal mucosa cells of patients with oral lichen planus (OLP) in relation to free radical toxicity since OLP is considered to be a precancerous lesion.MethodsThe micronucleus frequency in exfoliated buccal mucosa cells of patients with OLP was assessed and compared to those in healthy subjects.ResultsA significant increase (P<0.004) in frequency of micronucleated exfoliated cells (MEC) was observed in patients with OLP when compared to normal subjects.ConclusionsIt can be concluded that DNA damage in MEC of OLP patients may be a consequence of increased free radical toxicity.
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