钙蛋白酶-1表达水平与结直肠癌患者病理特征及疾病进展风险的相关性

目的探讨钙蛋白酶-1表达水平与结直肠癌患者病理特征及疾病进展风险的相关性。方法选取2017年2月至2018年9月就诊的107例结直肠癌手术患者,入院时收集患者临床病理资料及钙蛋白酶-1水平,所有患者均成功手术,随访1年截至末次随访时间2019年9月共有3名患者因不同原因失访,剩余104例患者均完成随访,其中36例患者出现疾病进展定义为进展组,68例未出现疾病进展定义为无进展组;对比分析两组患者临床资料,分析钙蛋白酶-1表达水平与结直肠癌病理特征;术后均根据患者肿瘤分期及部位等接受术后辅助治疗;采用多因素logistic回归分析结直肠癌患者疾病进展风险的独立预测因素;绘制工作特征曲线(ROC)评估钙蛋白酶-1表达水平对结直肠癌患者疾病进展风险的预测价值。结果两组病理特征肿瘤部位、N分期、M分期、肿瘤分化程度等比较差异无统计学意义(P>0.05);两组钙蛋白酶-1、淋巴转移、T分期比较,差异有统计学意义(P<0.05),多因素分析显示T分期(OR=2713.809)、淋巴转移(OR=118.177)、钙蛋白酶-1(OR=23.749)是结直肠癌患者疾病进展风险的独立预测因素,ROC曲线分析显示,钙蛋白酶-1结直肠癌患者疾病进展风险的AUC为0.716,高于T分期、淋巴转移(P<0.05)。结论钙蛋白酶-1在疾病进展患者中高表达,可作为预测结直肠癌患者疾病进展风险的标志物。

Correlation between the expression level of calpain-1 and the pathological characteristics and the risk of disease progression in patients with colorectal cancer

Objective To investigate the correlation between the expression of calpain-1 and the pathological characteristics and the risk of disease progression in patients with colorectal cancer. Methods A total of 107 colorectal cancer patients who had undergone surgery from February 2017 to September 2018 were selected. The clinicopathological data and calpain-1 levels of the patients were collected upon admission. all patients were successfully operated,followed up for 1 year as of the last follow-up time in September 2019. A total of 3 patients were lost for different reasons. The remaining 104 patients completed the follow-up,of which36 patients with disease progression were defined as the progression group,and 68 patients with no disease progression were defined as the progression-free group. The clinical data of the two groups of patients were compared and the expression level of calpain-1 was analyzed. The pathological characteristics of colorectal cancer;postoperative adjuvant treatment was received according to the tumor stage and location of the patient;Multivariate logistic regression was used to analyze independent predictors of disease progression risk in colorectal cancer patients;draw a working characteristic curve(ROC)to evaluate the predictive value of calpain-1 expression on the risk of disease progression in patients with colorectal cancer. Results There was no significant difference in pathological characteristics,tumor location,N staging,M staging,and tumor differentiation degree between the two groups(P>0.05);the comparison of calpain-1,lymphatic metastasis,and T staging between the two groups was statistically significant(P<0.05). Multivariate analysis showed that T stage(OR=2713.809),lymphatic metastasis(OR=118.177),calpain-1(OR=23.749)are independent predictors of the risk of disease progression in patients with colorectal cancer. ROC curve analysis showed that the AUC of calpain-1 in colorectal cancer patients with disease progression risk was 0.716,which was higher than T stage and lymphatic metastasis(P<0.05). Conclusion Calpain-1 is highly expressed in patients with disease progression and can be used as a marker to predict the risk of disease progression in patients with colorectal cancer.