Systemic mastocytosis: MRI of bone marrow involvement |
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Authors: | M Roca J Mota P Giraldo J A García Erce |
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Institution: | (1) Department of Radiology, Hospital Miguel Servet, Isabel la Católica 1–3, E-50009 Zaragoza, Spain, ES;(2) Department of Haematology, Hospital Miguel Servet, Isabel la Católica 1–3, E-50009 Zaragoza, Spain, ES |
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Abstract: | Systemic mastocytosis (SM) is an abnormal proliferation of mast cells, located in different structures: skin, bone marrow,
spleen, liver and lymph nodes. Magnetic resonance imaging was prospectively performed in ten patients diagnosed by bone marrow
biopsy in order to describe the different patterns of bone marrow involvement. Coronal T1-weighted spin-echo images were obtained
in vertebral, pelvic, humeral and femoral bones. Depending on the extension of the cell infiltration, three patterns of bone
marrow involvement were used: normal/no involvement (N), non-homogeneous (NH) and homogeneous (H). All ten patients presented
bone infiltration. The patterns observed were: spine (50 % NH, 50 % H), pelvis (70 % NH), humerus 100(NH) and femur 40 % (NH).
T1-weighted MR imaging is a sensitive technique for detecting marrow abnormalities in patients with systemic mastocytosis.
There is no correlation between percentage of mast cells in bone marrow biopsy and extent or pattern of bone marrow involvement.
Received: 5 June 1998; Revision received: 23 November 1998; Accepted: 15 January 1999 |
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Keywords: | : MR imaging Bone marrow Systemic mastocytosis |
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