| HPLC法测定盐酸左旋沙丁胺醇缓释胶囊的有关物质 |
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| 引用本文： | 齐潇潇,邓红,林华庆,张蜀,余楚钦.HPLC法测定盐酸左旋沙丁胺醇缓释胶囊的有关物质[J].广东药学院学报,2009,25(1):49-51. |
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| 作者姓名： | 齐潇潇 邓红 林华庆 张蜀 余楚钦 |
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| 作者单位： | 广东药学院药物研究所/广东药物新剂型重点实验室,广东广州,510006 |
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| 摘 要： | 目的测定盐酸左旋沙丁胺醇缓释胶囊的有关物质。方法采用反相高效液相色谱法（RP-HPLC法）,色谱柱为Kromasil C18柱（250 mm×4.6 mm,5μm）,以甲醇-磷酸盐缓冲液（取磷酸二氢钠9.77 g,加水溶解并稀释至1 000 mL,用磷酸调节pH值至3.10±0.05）（体积比20∶80）为流动相,检测波长为224 nm,流速1.0 mL.min-1。结果各杂质峰分离良好,左旋沙丁胺醇的最低检测限为14 ng。结论本法可用于盐酸左旋沙丁胺醇缓释胶囊中有关物质的检测。
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| 关 键 词： | 盐酸左旋沙丁胺醇 缓释胶囊 有关物质 高效液相色谱法 |
Analysis of levalbuterol hydrochloride sustained release capsules by RP-HPLC |
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| QI Xiao-xiao,DENG Hong,LIN Hua-qing,ZHANG Shu,YU Chu-qin.Analysis of levalbuterol hydrochloride sustained release capsules by RP-HPLC[J].Academic Journal of Guangdong College of Pharmacy,2009,25(1):49-51. |
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| Authors: | QI Xiao-xiao DENG Hong LIN Hua-qing ZHANG Shu YU Chu-qin |
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| Institution: | QI Xiao-xiao,DENG Hong,LIN Hua-qing,ZHANG Shu and YU Chu-qin(Institute of Meteria Medica,Guangdong Pharmaceutical College,Key Laboratory of Advanced Drug Delivery of Guangdong Province,Guangzhou,Guangdong 510006,China) |
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| Abstract: | Objective To establish an HPLC method for analyzing levalbuterol hydrochloride sustained- release capsules. Methods Samples were analyzed on a Kromasil-column （250 mm × 4.6 mm, 5 μm）. The mobile phase consisted of methanol-PBS （9. 77 g sodium dihydrogen phosphate in 1 L of water, adjusted to pH 3.10 ± 0.05 with phosphoric acid） （20：80）. The detection wavelength was 224 nm and the flow rate l. 0 mL · min^-1. Results Impurities were separated well from each other, and the detection limit of levalbuterol hydrochloride was 14 ng. Conclusion This method is suitable for the quality of levalbuterol hydrochloride sustained-release capsules. |
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| Keywords: | levalbuterohydrochloride sustained-release capsules RP-HPLC |
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