| 生理因素对纹状体多巴胺D2受体表达的影响 |
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| 引用本文： | 曹国祥,谭天秩. 生理因素对纹状体多巴胺D2受体表达的影响[J]. 四川大学学报(医学版), 2000, 31(1): 5-6 |
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| 作者姓名： | 曹国祥 谭天秩 |
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| 作者单位： | 华西医科大学附属第一医院,核医学科,成都,610041 |
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| 基金项目： | 卫生部科研项目，94-2-166， |
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| 摘 要： | 为了研究大鼠的品系、性别和年龄相关的体重因素对纹状体多巴胺D2受体表达的影响,用大鼠纹状体和125I-IBZM{(S)-3-碘-2-羟基-6-甲氧基-N-[(1-乙基-2-吡咯烷基)甲基]苯甲酰胺}结合,按照大鼠的品系、性别和年龄相关的体重进行组间配对比较.结果:大鼠的品系和性别对纹状体多巴胺D2受体的125I-IBZM结合无明显影响,但纹状体多巴胺D2受体的125I-IBZM结合却有体重相关性的减少.由此表明,纹状体多巴胺D2受体可能具有年龄依赖性的减少.因此,在临床研究中严格的年龄配对是必须的.
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| 关 键 词： | 多巴胺D2受体 生理因素 |
The Influence of Physiologic Factors on the Expression of Striatal Dopamine D2 Receptors |
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| Cao Guoxiang,Tan Tianzhi. The Influence of Physiologic Factors on the Expression of Striatal Dopamine D2 Receptors[J]. Journal of Sichuan University. Medical science edition, 2000, 31(1): 5-6 |
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| Authors: | Cao Guoxiang Tan Tianzhi |
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| Abstract: | The aim of this study was to know whether the strain, sex, and age related body weight of rat have influence on the expression of striatal dopamine D 2 receptor. The data on striatal dopamine D 2 receptor binding 125 I IBZM in 34 rats were used in the comparison between pairs of groups matched on strain, sex, and body weight. The result showed that the strain and sex of rats had no influence on the striatal dopamine D 2 receptor binding 125 I IBZM, but there was a body weight related decrease in the striatal dopamine D 2 receptor binding 125 I IBZM.The results suggest that age dependent decline of striatal dopamine D 2 receptors is possible; therefore, strict age matching is necessary to clinical studies. |
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| Keywords: | Dopamine D_2 receptor Physiologic factors |
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