| 人胎脑组织中低分子抗衰老物质的实验研究 |
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| 引用本文： | 周少雄 肖桂元. 人胎脑组织中低分子抗衰老物质的实验研究[J]. 中国老年学杂志, 1996, 16(6): 366-369 |
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| 作者姓名： | 周少雄 肖桂元 |
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| 作者单位： | 湛江市中心人民医院 |
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| 基金项目： | 广东省第四批重点科技攻关项目 |
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| 摘 要： | 采用细胞内脂褐素测定和体外神经细胞培养这两个基本指标观察了人胎脑组织提取液（Ｆｅｔａｌｂｒａｉｎｅｘｔｒａｃｔｓ，ＦＢＥ）的抗衰老作用。分析表明：ＦＢＥ中分子量小于２０ｋＤａ的组份能预防老龄小鼠脑神经元内脂褐素沉积，该预防作用的原因之一是ＦＢＥ能提高脑细胞线粒体谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活力。ＦＢＥ加入人胚神经细胞培养体系中能促进神经元生长和防止神经突起萎缩。ＦＢＥ有可能成为治疗中枢神经系统变性疾患尤其帕金森病的神经保护药物。
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| 关 键 词： | 人胎脑提取液，抗衰老，脂褐素，谷胱甘肽过氧化物酶，神经细胞 |
Low molecular antiaging substances in human fetal brain extracts |
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| Zhou Shaoxiong, Dai Shengming,Xiao Guiyuan. Low molecular antiaging substances in human fetal brain extracts[J]. Chinese Journal of Gerontology, 1996, 16(6): 366-369 |
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| Authors: | Zhou Shaoxiong Dai Shengming Xiao Guiyuan |
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| Abstract: | Antiaging fractions in human Fetal Brain Extracts (FBE) were studied and the results indicated that the MW<20000 fractions of FBE might halt the lipofuscin collecting in the aged mouse neurocyte. The mechauism suggested was FBE might enhance glutathione peroxidase activities in the mitochondria of the aged mouse neurocyte. FBE might promoted the growth of neurocyte and prevent the process of atrophy when human embryonic neurocytes were added in the culture in vitro. It is suggested that FBE might be used as a potential neuroprotection in clinical trials for the treatment of neurodegenerative diseases such as Parkinson's disease. |
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| Keywords: | Fetal brain extracts Antiaging Lipofuscin Glutathione Peroxidase Neurocyte |
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