依帕司他联合前列地尔治疗糖尿病周围神经病变的临床观察

目的：观察依帕司他联合前列地尔治疗糖尿病周围神经病变（DPN）的疗效。方法：将76例DPN患者随机分为2组：治疗组39例，静脉滴注前列地尔10μg／d，口服依帕司他3次／天，每次50mg；对照组37例，口服维生素B1，每次10mg，3次／天代替依帕司他，其余同治疗组。2组均治疗4周。记录治疗前后主症状、体征及肌电图的改变。结果：治疗组临床疗效和神经传导速度改善均优于对照组（P〈0．01）。结论：依帕司他联合前列地尔治疗DPN安全有效，且临床疗效优于维生素B，联合前列地尔。

Epalrestat combined with alprostadil for treatment of diabetic peripheral neuropathy

Objective ：To observe the clinical effect of epalrestat combined with alprostadil on diabetic peripheral neuropathy（DPN）. Methods：Seventy-six patients with DPN were randomly divided into two groups. The treatment group （39 cases） were administered intravenous infusion of alprostadil （ 10 μg/d） and oral epalrestat （50 mg/time, 3 times/d）, while the control group （ 37 cases ） were treated with intravenous infusion of alprostadil（ 10 μg/d） and oral vitamin B1 （10 mg/time,3 times/d）. The patients＇ symptoms,signs and changes of electromyography were compared before and after treatment. Results： The treatment group were superior to the control group in clinical efficacy and improvement of the nerve conduction velocity （P 〈 0.01 ）. Conclusions： Epalrestat combined with alprostadil is safe and effective in the treatment of diabetic peripheral neuropathy, and the curative effect is better than the therapy of vitamin B1 combined with alprostadil.