侵袭性垂体腺瘤MRI表现与Gal-3、MMP-2表达的相关性

目的：探讨垂体腺瘤MRI侵袭特征与半乳糖凝集素3（Gal-3）和基质蛋白金属酶-2（MMP-2）表达的相关性.方法：对43例垂体腺瘤患者术前行MRI检查,收集术后标本并采用免疫组织化学S-P法诊断侵袭性垂体腺瘤（IPA,26例）和非IPA（17例）组织中Gal-3与MMP-2的表达,分析Gal-3和MMP-2之间的关系.结果：IPA组中Gal-3、MMP-2表达的阳性率均高于非IPA组（P＜0.01）.Gal-3和MMP-2在IPA组织的表达中呈正相关关系（P＜0.01）.结论：Gal-3、MMP-2的表达与垂体腺瘤的侵袭性生长密切相关,可作为判断垂体腺瘤有无侵袭性的潜在分子标志物;裂解的Gal-3片段可能在垂体腺瘤的侵袭中起重要作用,并可能为在分子治疗IPA提供有用的治疗靶标.

Association of MRI features of invasive pituitary adenoma with the expression of galectin-3 and matrixmetallop roteinase-2

Objective：To explore the association of MRI features of invasive and noninvasive pituitary adenomas with the expressions of galectin-3 （ Gal-3 ） and matrixmetalloproteinase-2 （MMP-2）. Methods ： MRI was perfoimed preoperatively on 43 patients with histologically verified pituitary adenomas;immunohistochemistry was applied to detect the protein expressions of Gal-3 and MMP-2 in the invasive and non-invasive pituitary adenomas tissues. The MRI features and their correlation with the expressions of Gal-3 and MMP-2 were analyzed. Results：The expressions of Gal-3 and MMP-2 in the invasive pituitary adenomas were significantly higher than those in the non-invasive pituitary adenomas（P 〈 0.01 ）. The Gal-3 and MMP-2 was positively correlated in invasive pituitary adenomas （P 〈 0.01 ）. Conclusions ：The expressions of Gal-3 and MMP-2 are closely associated with the aggressiveness of the pituitary adenoma, which may act as potential molecular markers for assessment of the invasive potential of pituitary adenomas. The cleavage of Gal-3 might be responsible for the tumorigenic potential of the cells and provide useful targets for molecular therapeutic strategy against invasive pituitary adenomas.