大剂量氨溴索治疗重度支气管哮喘急性发作40例临床观察

目的探讨大剂量氨溴索治疗重度支气管哮喘急性发作的临床效果。方法选择该院2010年3月—2012年3月重度支气管哮喘患者共80例,上述患者均符合支气管哮喘诊断标准,均为急性发作患者,病程程度为重度。上述患者随机分为观察组和对照组。两组患者均给予重度支气管哮喘急性发作常规治疗,观察组同时给予大剂量氨溴索静脉滴注,连续应用7d。观察两组患者临床症状和体征消失时间及治疗前后肺功能改善情况。结果观察组患者患者临床症状和体征消失时间为（8.1±3.5）d;对照组患者患者临床症状和体征消失时间为（14.5±4.1）d;观察组患者临床症状和体征消失时间显著早于对照组,差异有统计学意义（P〈0.05）;观察组治疗后FEV1、FEV1/FVC、PEF分别与对照组治疗后比较,差异有统计学意义（P〈0.05）。结论大剂量氨溴索治疗重度支气管哮喘急性发作辅助作用显著,能够缩短患者临床症状消失时间,提高治疗效果,值得借鉴。

Large dose of Ambroxol Hydrochloride in Treatment of Severe Acute Attack of Bronchial Asthma:Clinical Observation of 40 Cases

Objective To study of large dose of ambroxol hydrochloride in treatment of severe bronchial asthma acute attack clinical effect. Methods In our hospital from 2010 March to 2012 March a total of 80 patients with severe bronchial asthma patients, the patients were consistent with bronchial asthma diagnostic criteria, were in patients with acute exacerbation of severe degree, course of disease. The patients were randomly divided into observation group and control group. Two groups of patients were given severe acute attack of bronchial asthma with conventional treatment, the observation group while giving a large dose of ambroxol hydrochloride intravenous injection, continuous application for 7 days. Observation of two patients with clinical symptoms and signs disappearing time and improvement of pulmonary function before and after treatment. Results Patients in observation group in patients with clinical symptoms and signs disappear time was （8.1±3.5） d; the control group of patients with clinical symptoms and signs disappear time was （14.5±4.1） d; observation group of patients with clinical symptoms and signs disappear time significantly earlier than in the control group, the difference has statistics significance （P〈0.05）; the observation group were treated with after FEV1, FEV1VFVC, PEF respectively, and the comparison of the two groups, the difference was statistically significant （P〈0.05）. Conclusion Large dose of ambroxol hydrochloride in treatment of severe acute attack of bronchial asthma with auxiliary effect, can reduce the patients＇ clinical symptoms disappeared time, improve the therapeutic effect, worthy of reference.