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多孔HA/PU复合支架材料生物相容性的评估
引用本文:董志红,李玉宝,邹琴,李吉东. 多孔HA/PU复合支架材料生物相容性的评估[J]. 中国生物医学工程学报, 2008, 27(6)
作者姓名:董志红  李玉宝  邹琴  李吉东
作者单位:四川大学纳米生物材料研究中心分析测试中心,成都,610064
基金项目:国家重点基础研究发展规划(973计划)  
摘    要:进行了三维多孔立体结构的纳米羟基磷灰石/聚氨酯(HA/PU)复合支架材料体外细胞培养和体内肌肉埋植实验研究,评估材料的生物相容性。实验选用SD大鼠的骨髓基质干细胞(BMSCs)和健康的SD雌性大鼠,进行细胞相容性、形态学观察和组织学切片分析。HA/PU支架材料的多孔性为细胞的生长提供了良好的微环境,细胞在内部贴壁爬行、增殖并分化,细胞毒性为零级,材料与周围组织有良好的结合,降解的空间有结缔组织纤维长入。实验表明,HA/PU复合支架材料具有良好的细胞亲和性和组织学相容性,可作为一类新型组织工程支架材料。

关 键 词:多孔HMPU支架材料  生物相容性  降解性

Evaluation on Biocompatibility of Porous HA/PU Composite Scaffold
DONG Zhi-Hong,LI Yu-Bao,ZOU Qin,LI Ji-Dong. Evaluation on Biocompatibility of Porous HA/PU Composite Scaffold[J]. Chinese Journal of Biomedical Engineering, 2008, 27(6)
Authors:DONG Zhi-Hong  LI Yu-Bao  ZOU Qin  LI Ji-Dong
Abstract:The aim of this study is to evaluate the biocompatibility of three dimensions porous scaffold of nano-hydroxyapatite/polyurethane (HA/PU) composite. Mice's bone marrow stromal stem cells (BMSCs) and healthy SD female mice were used for cell culture test in vitro and muscle implant test in vivo respectively. Cytocompatibility, morphology and histology were analyzed. Porosity of HA/PU composite scaffold provides good microenvironment for cell growth. BMSCs were capable of growth, proliferation and differentiation on the surface of HA/PU scaffold and its pores. Cytotoxicity was zero level. Surrounding tissues fibers grow into the pores and the sites degraded from porous HA/PU scaffolds, which show that HA/PU composite scaffolds have a good cellular affinity and histological biocompatibility for tissue engineering scaffolds.
Keywords:porous HA/PU scaffold  biocompatibility  degradation
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