宫颈癌EGFR和VEGF的表达及相关性研究

目的探讨宫颈癌中EGFR及VEGF的表达与宫颈癌的关系及其相关性。方法采用免疫组化EnVision法检测80例宫颈癌组织芯片中EGFR和VEGF的表达,分析其与宫颈癌临床病理特征的关系及其间相关性。结果宫颈癌中的EGFR和VEGF阳性表达率分别为94.8%、79.1%,癌旁组织中的表达率分别为15%、20%。两者在两种组织中的表达有显著差异(P<0.01)。EGFR表达与肿瘤大小、组织类型、病理分级、浸润深度、淋巴结转移、临床分期有关(P<0.05);VEGF与肿瘤大小、淋巴结转移、临床分期有关(P<0.05);EGFR和VEGF表达两者之间有显著性相关性(r=0.2548,P<0.05)。结论 EGFR和VEGF高表达与宫颈癌的生长、浸润转移及预后有相关性,两者在宫颈癌的发展中可能存在协同作用。

Expression and correlation of EGFR and VEGF in cervical carcinoma

Objective To study the relationship between the expressions of EGFR, VEGF in cervical carcinoma and to observe the correlation between EGFR and VEGF in them. Methods The expressions of EGFR and VEGF were studied by immunohistochemical EnVision in tissue microarray containing 80 cervical carcinoma tissues and the corresponding adjacent tissues. The relationship between EGFR and VEGF expression and the chinicopathological features was ana- lyzed. Results The positive rates of EGFR and VEGF were 94.8% and 79.1% respectively in cervical carcinoma. How- ever they were 15% and 20% respectively in the corresponding adjacent tissues. Expressions of EGFR and VEGF pro- teins were significantly higher in cervical carcinoma than those in adjacent tissues （P〈O.01）. The overexpression of EGFR was found significantly associated with the tumer size,tissue type,differentiation degree, knubbly invasive depth, lymphnode metastasis and clinical stage（P〈0.05）. That of VEGF found significantly associated with the turner size,lym- phnode metastasis and clinical stage （P〈0.05）. Besides, the overexpression of EGFR was correlated with the overexpres- sion of VEGF （r=0.2548, P〈0.05）. Conclusion The overexpression of EGFR and VEGF in cervical carcinoma are closely correlated with the growth, invasion and metastasis, prognosis , and maybe have synergistic effect in develop- ment of cervical carcinoma.