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Direct evidence of the temperature dependence of Gd-BOPTA transport in the intact rat liver

Authors:	Corinne Planchamp Gerd J Beyer Daniel O Slosman Franois Terrier Catherine M Pastor

Institution:	Laboratoire de physiopathologie hépatique, et imagerie moléculaire, Département de Radiologie, Hôpitaux Universitaires de Genève, Rue Micheli-du-Crest 24, CH-1211 Genève 14, Switzerland

Abstract:	The aim was to study the influence of temperature on the transport of the hepatobiliary contrast agent Gadobenate dimeglumine (Gd-BOPTA). Rat livers were isolated and perfused with Gd-BOPTA at 12, 25, 30, 36 and 38 °C. After the perfusion period, biopsies were collected and the MR signal intensity was measured. Uptake and biliary excretion were quantified with radiolabeled Gd-BOPTA. MR signal intensity decreased with temperature of perfusion. This phenomenon was appropriately quantified with ¹⁵³Gd and ¹⁵³Sm labeling, in contrast to ⁶⁷Ga.

Keywords:	Cellular imaging Gd-BOPTA Hepatocytes Isolated perfused rat liver Magnetic resonance imaging Radiolabeling
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