| 维生素A和布地奈德对哮喘大鼠外周血T细胞亚群和调节性T细胞的影响 |
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| 引用本文： | 何金根,潘家华,楼皖玲,刘辉. 维生素A和布地奈德对哮喘大鼠外周血T细胞亚群和调节性T细胞的影响[J]. 蚌埠医学院学报, 2011, 36(5): 452-455 |
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| 作者姓名： | 何金根 潘家华 楼皖玲 刘辉 |
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| 作者单位： | 安徽医科大学附属省立医院儿科,安徽,合肥,230001;安徽医科大学,生理学教研室,安徽,合肥,230032 |
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| 摘 要： | 目的：探讨维生素A（Vit A）和布地奈德对哮喘大鼠外周血T细胞亚群和CD4＋CD25＋调节性T细胞（CD4＋CD25＋regulatory Tcell,CD4＋CD25＋Treg）的影响,为其在哮喘防治中的应用提供实验依据。方法：将42只SD大鼠用卵蛋白建立哮喘模型,随机分成布地奈德治疗组、Vit A治疗组和哮喘对照组,每组各14只,各组干预1周,于第4周和第5周取外周血50μl,流式细胞术检测T细胞亚群及Treg细胞变化。结果：激发后第4周,Vit A组CD3＋T细胞、CD4＋CD25＋Treg细胞显著高于布地奈德组（P〈0.05）,CD3＋CD8＋T细胞均低于布地奈德组（P〈0.05）;布地奈德组CD4＋CD25＋Treg细胞显著低于哮喘组（P〈0.01）;激发后第5周,布地奈德组CD4＋CD25＋Treg细胞低于哮喘组（P〈0.05）。结论：雾化吸入Vit A可减轻哮喘大鼠炎症反应,这一作用可能与哮喘大鼠外周血CD3＋T细胞和CD4＋CD25＋Treg细胞升高、CD8＋T细胞降低有关。
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| 关 键 词： | 哮喘 维生素A T细胞亚群 CD4+ CD25+ 调节性T细胞 大鼠 |
The effects of vitamin A and budesonide on serum T-lymphocyte subsets and CD4~+CD25~+ regulatory T cells in rat asthma model |
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| HE Jin-gen,PAN Jia-hua,LOU Wan-ling,LIU Hui. The effects of vitamin A and budesonide on serum T-lymphocyte subsets and CD4~+CD25~+ regulatory T cells in rat asthma model[J]. Journal of Bengbu Medical College, 2011, 36(5): 452-455 |
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| Authors: | HE Jin-gen PAN Jia-hua LOU Wan-ling LIU Hui |
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| Affiliation: | HE Jin-gen1,PAN Jia-hua1,LOU Wan-ling2,LIU Hui1(1.Department of Pediatrics,Anhui Provincial Hospital of Anhui Medical University,Hefei Anhui 230001,2.Department of Physiology,Anhui Medical University,Hefei Anhui 230032,China) |
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| Abstract: | Objective:To investigate the effects of vitamin A and budesonide on peripheral blood T-lymphocyte subsets and CD4+CD25 +Treg cells in rat asthma model,which provide the experimental basis for vitamin A in the prevention and treatment of bronchial asthma.Methods:Forty-two adult female SD rats were divided into three groups,the budesonide group,vitamin A group and asthma group.There were 14 rats in each group.The peripheral blood was conducted to determinate T-lymphocyte subsets and CD4+CD25 +Treg by flow cyt... |
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| Keywords: | CD4+ CD25+ |
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