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| N-(3-三氟甲基苯基)维甲酰胺对人肺腺癌A549细胞迁移能力的影响及其可能机制 | |
| 引用本文： | 王银凤,程英,桂淑玉,陈飞虎,周青,汪渊.N-(3-三氟甲基苯基)维甲酰胺对人肺腺癌A549细胞迁移能力的影响及其可能机制[J].安徽医科大学学报,2011,46(5):439-442. |
| 作者姓名： | 王银凤 程英 桂淑玉 陈飞虎 周青 汪渊 |
| 作者单位： | 1. 安徽医科大学第一附属医院呼吸内科,合肥,230022 2. 安徽医科大学第一附属医院呼吸内科,合肥,230022;安徽医科大学分子生物学实验室和安徽省重要遗传疾病基因资源利用重点实验室,合肥,230032 3. 安徽医科大学药学院,合肥,230032 4. 安徽医科大学分子生物学实验室和安徽省重要遗传疾病基因资源利用重点实验室,合肥,230032 |
| 基金项目： | 国家自然科学基金，安徽省自然科学基金 |
| 摘 要： | 目的 研究全反式维甲酸(ATRA)衍生物N-(3-三氟甲基苯基)维甲酰胺,NTFMP]对人肺腺癌A549细胞株迁移能力的影响及其可能机制.方法 应用细胞迁移实验分析NTFMP对A549细胞迁移能力的影响,Western blot检测NTFMP对肌球蛋白轻链激酶(MLCK)的表达和肌球蛋白轻链(MLC)磷酸化的影响.结... |
| 关 键 词： | 肺肿瘤 细胞运动/药物作用 维甲酸/类似物和衍生物 肌球蛋白轻链激酶 |
Effects and its probable mechanism of N-(3-trifluoromethyl-phenyl)-retinamide on the migration ability of human lung adenocarcinoma A549 cells |
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| Wang Yinfeng,Cheng Ying,Gui Shuyu,et al.Effects and its probable mechanism of N-(3-trifluoromethyl-phenyl)-retinamide on the migration ability of human lung adenocarcinoma A549 cells[J].Acta Universitis Medicinalis Anhui,2011,46(5):439-442. | |
| Authors: | Wang Yinfeng Cheng Ying Gui Shuyu |
| Institution: | Wang Yinfeng1,Cheng Ying1,Gui Shuyu1,2,et al(1Dept of Respiratory Medicine,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,2Laboratory of Molecular Biology,Anhui Medical University,Key Laboratory of Gene Resorce Utilizationfor Genetic Diseases of Anhui Province,Hefei 230032) |
| Abstract: | Objective To investigate the effects and its probable mechanism of N-(3-trifluoromethyl-phenyl)-retinamide(NTFMP)on the migration ability of human lung adenocarcinoma A549 cells.Methods The effect of NTFMP on the migration of A549 cells was analyzed by cell migration test and the expression of myosin light chain kinase(MLCK)and phosphorylation of myosin light chain(pMLC)proteins was detected by Western blot.Results 1,7.5 mg/L NTFMP could inhibit the cell migration distance of A549 cells.The migration distan... |
| Keywords: | lung neoplasms cell movement/drug effect tretinoin/analogs & derivatives myosin-light-chain kinase |
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