C-反应蛋白和降钙素原在诊断早产儿坏死性小肠结肠炎中的比较

目的比较C反应蛋白（CRP）和降钙素原（PCT）在诊断早产儿坏死性小肠结肠炎（NEE）与其随访中的有效性。方法120例新生儿被纳入这项研究，这些新生儿被分为三组：组1（NEC伴败血症患儿，n=40），组2（败血症患儿，n=40），组3（健康儿，n=40）。收集这些新生儿在0、24、48h及7、10d时间点的全血计数、CRP、PET数据并分析。结果组1的白细胞平均计数（6958±2754）、（7285±2576）、（7354±2684）、（7658±2147）、（7985±2587）个／mm2在各时间点低于组2（9423±2475）、（8798±2147）、（8476±1987）、（8247±2014）、（7989±2145）个／mm2和组3（7354±2146）个／mm2，但差异无统计学意义（P〉0．05）。组1的平均血小板计数（123149±45876）、（98745±41786）、（99874±42364）、（112546±45876）、（142547±41258）个／mm2在各时间点均低于组2（187452±47852）、（179624±36875）、（174562±34828）、（198754±42578）、（247895±35741）个／mm2与组3（248754±57891）个／mm2。组1中CRP水平8．4、6．0、5．9、3．2、1．1ng／mL在各时间点明显高于组22．8、3．0、3.3、1．7、0．5ng／mL与组30．4ng／mL，而PCT水平7．5、5．4、3．7、1．9、0．6ng／mL虽然高于对照组0．4ng／mL，但与组26．8、4．5、3．6、1．8、0．5ng／mL比较，差异无统计学意义（P〉0．05）。结论CRP与PCT都是可配合临床与透视检查诊断NEC的可靠标志物，连续单独或联合检测CRP与PCT可安全应用于NEC的诊断与随访中。

Comparison of C-reactive protein and procalcitonin in the diagnosis of premature infants with necrotizing enterocolitis

Objective To compare the effectiveness of C-reactive protein （CRP） and procalcitonin （PCT） in diagnosis and follow-up for preterm infants with necrotizing enterocolitis （NEC）. Methods 120 infants were enrolled into this study. These infants were divided into 3 groups： group 1 （40 infants with NEC）, group 2 （40 infants with sepsis）, group 3 （40 healthy infants）. The data of whole blood count, CRP, PCT from these infants were collected and analyzed at 0, 24, 48 h and 7, 10 d. Results Mean white blood cell count in group 1 （6 958±2754）,（7 285±2 576）,（7 354±2 684）,（7 658± 2 147）,（7 985±2 587）/mm2 was lower than that in group 2 （9 423±2 475）,（8 798±2 147）,（8 476±1 987）,（8 247±2 014）, （7 989±2 145）/mm2 and group 3 （7 354±2 146）/mm2, but there was no significant difference, whereas mean platelet count in group 1 （123 149±45876）,（98 745±41 786）,（99 874±42 364）,（112 546±45 876）,（142 547±41 258）/mm2 was significantly lower than that in group 2 （187 452±47 852）,（179 624±36 875）,（174 562±34 828）, （198 754±42578）, （247 895±35 741） and group 3 （24 8754±57 891）. The CRP levels of infants in group 1 8.4, 6.0, 5.9, 3.2, 1.1 ng/mL at vari- ous time point were significantly higher than those in group 2 2.8, 3.0, 3.3, 1.7, 0.5 ng/mL and 3 0.4 ng/mL. PCT level 7.5, 5.4, 3.7, 1.9, 0.6 ng/mL were significantly higher than those in control group 0.4 ng/mL, but there were no signifi- cant difference compared with group 2 6.8, 4.5, 3.6, 1.8, 0.5 ng/mL. Conclusion CRP and PCT all are reliable markers which asist clinical and radiographic findings for diagnosis of NEC. Consecutive measurements of CRP and PCT , ei- ther alone or in combination, can be utilized safely in diagnosis and follow-up of NEC.