良性前列腺增生组织中VEGF Flt-1表达及与微血管密度计数相关性研究

目的 探讨良性前列腺增生组织中VEGF、Flt-1表达和MVD计数的相关性.方法 采用免疫组织化学S-P法,检测37例良性前列腺增生组织VEGF、Flt-1表达和MVD计数,进行等级相关性分析.结果 VEGF表达与MVD计数呈正相关(P＜0.05),VEGF与Flt-1表达呈正相关(P＜0.05),Flt-1表达与MVD计数无相关性(P＞0.05);前列腺体积与VEGF、Flt-1表达和MVD计数均无相关性(P＞0.05).结论 在前列腺增生过程中VEGF与Flt-1表达呈正相关,与MVD也呈正相关.

The Correclate of MVD And The Expression of VEGF Flt-1 In Benign Prostatic Hyperplasia

Objective To study the correclate of MVD and the expression of VEGF and Flt-1 in benign prostatic hyperplasia(BPH).Methods Immunohistochemical staining(S-P) was used to examine MVD and the expression of VEGF and Flt-1 in 37 cases of BPH,Spearman rank correlation test were used for data statistic analysis.Results There was positive correlation betweenthe expression of VEGF and MVD Coumts,and FIt-1 expression(P<0.05),but there wasn't correlate between FIt-1 expression and MVD counts,There was no correlation between the size of prostate and MVD and the expression of both VEGF and Flt-1 in BPH(P>0.05).Conclusion In the progress of benign prostatic hyperplasia,There were positive correlate between VEGF ancl Flt-1 and MVD.