| 多指标综合评分法研究中药半浸膏片的制粒工艺 |
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| 引用本文： | 张源,周琴妹,王璐.多指标综合评分法研究中药半浸膏片的制粒工艺[J].中国药师,2011,14(2):182-185. |
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| 作者姓名： | 张源 周琴妹 王璐 |
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| 作者单位： | 1. 江苏省中医院制剂部,南京,210029
2. 南京中医药大学 |
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| 基金项目： | 江苏省中医药管理局课题 |
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| 摘 要： | 目的:以冠心平为模型药物,优选中药半浸膏片的制粒最佳工艺。方法:通过单因素考察,确定制粒的最佳粘合剂;采用L9（34）正交试验法,以粘合剂浓度、用量及软材搅拌时间作为考察因素,通过颗粒粉体学和片芯的几个质量指标的综合评分,优选出冠心平片的最佳（湿法）制粒工艺。结果:最佳工艺条件为:采用2%浓度的羟丙甲基纤维素浆溶液,用量为浸膏粉量的26%,软材混合时间为8 min。结论:确定的制粒工序生产工艺参数适用于冠心平片的制粒。
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| 关 键 词： | 冠心平 制粒 工艺研究 正交试验法 |
Study on Granulating Process of Semi-Extract Tablets of TCM by Multi-index test |
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| Zhang Yuan,Zhou Qinmei,Wang lu.Study on Granulating Process of Semi-Extract Tablets of TCM by Multi-index test[J].China Pharmacist,2011,14(2):182-185. |
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| Authors: | Zhang Yuan Zhou Qinmei Wang lu |
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| Institution: | Zhang Yuan~1,Zhou Qinmei~1,Wang lu~2(1.Department of Preparation,Jiangsu Hospital of Traditional Chinese Medicine,Nanjing 210029,China,2.Nanjing University of Traditional Chinese Medicine) |
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| Abstract: | Objective:To optimize the best granulating technology of semi-extract tablets of TCM using Glianxinping tablets as the model.Method:The optimal adhesive was chosen by single factor experiment.The concentration and amount of adhesive and stirring time of soft material as the influence factors,granule micromeritic properties and tablet core properties as the indices,the best preparation technology of Guanxinping tablets was optimized according to L_9(3~4) orthogonal design.Result:The optimum preparation condi... |
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| Keywords: | Guanxinping tablets Granulation Technical study Orthogonal design |
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