| 复方双参口腔崩解片的制备工艺研究 |
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| 引用本文： | 尹东锋,刘璟,陈效,薛雯婷,曾平. 复方双参口腔崩解片的制备工艺研究[J]. 中国药师, 2011, 14(3): 311-314 |
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| 作者姓名： | 尹东锋 刘璟 陈效 薛雯婷 曾平 |
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| 作者单位： | 1. 兰州军区乌鲁木齐总医院药剂科,乌鲁木齐,830000
2. 新疆农业大学药学院 |
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| 基金项目： | 兰州军区医药卫生科研项目 |
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| 摘 要： | 目的：制备复方双参口腔崩解片，使用星点设计-效应面优化法对处方工艺进行优化筛选。方法：以丹参水提物和人参皂苷为主药，采用粉末直接压片法制备复方双参口腔崩解片，选择MCC／L—HPC（8：2）和PVPP作为联合崩解剂。以MCC／L—HPC的用量及PVPP的用量为考察因素，崩解时限作为评价指标，用线性方程和二次及三次多项式描述崩解时限和两个影响因素之间的数学关系，根据最佳数学模型描绘效应面及等高线图，选择最佳处方，并进行预测分析。结果：当MCC／L—HPC含量25％，PVPP含量8．2％时，片剂的崩解时间最短。各指标的三项式拟合方程均优于多元线形回归方程，建立的数学模型的预测值与实际值符合较好。结论：用星点设计-效应面法优化复方双参口腔崩解片处方工艺预测性良好。
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| 关 键 词： | 复方双参口腔崩解片 丹参水提物 人参皂苷 崩解剂 星点设计 效应面 |
Study on Preparation of Compound Shuangshen Orally Disintegrating Tablets |
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| Yin Dongfeng,Liu Jing,Chen Xiao,Xue Wenting,Zeng Ping. Study on Preparation of Compound Shuangshen Orally Disintegrating Tablets[J]. China Pharmacist, 2011, 14(3): 311-314 |
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| Authors: | Yin Dongfeng Liu Jing Chen Xiao Xue Wenting Zeng Ping |
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| Affiliation: | Yin Dongfeng~1,Liu Jing~1,Chen Xiao~1,Xue Wenting~2,Zeng Ping~1(1.Department of Pharmacy,Urumqi General Hospital,Lanzhou Military Region of PLA,Urumqi 830000,China,2.School of Pharmacy,Xinjiang Agricultural University) |
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| Abstract: | Objective:To prepare the compound Shuangshen orally disintegrating tablets and optimize the formulation by a central composite design/response surface methodology.Method:The compound Shuangshen orally disintegrating tablets were prepared by direct powder compression with the water extract of salvia miltiorrhiza and ginsenosides as the mainly effective components.MCC/L-HPC (8:2) and PVPP were selected as the disintegrants.Independent variables were MCC/L-HPC content and PVPP content,and disintegrating time w... |
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| Keywords: | Compound Shuangshen orally disintegrating tablets Water extract of salvia miltiorrhiza Ginsenosides Disintegrant Central composite design Response surface |
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