关节液和血清中瘦素含量与膝关节滑膜炎之间的关系

目的探讨膝关节液和血清中瘦素含量与膝关节滑膜炎之间的关系。方法收集行膝关节镜手术患者血清和关节液95例,采用酶联免疫吸附试验(ELISA)法对其血清和关节液中的瘦素浓度进行检测。在关节镜下,对膝关节滑膜炎的炎症程度采用Ayral评分方法进行评测。结果骨关节炎患者关节液和血清中瘦素浓度(39±9)ng/ml;(26±8)ng/ml]较非骨关节炎患者中的浓度(17±6)ng/ml;(19±8)ng/ml]明显增高(P<0.05)。所有患者关节液中瘦素浓度与Ayral评分呈正相关(r=0.678,P=0.000);所有患者血清中瘦素浓度与Ayral评分呈正相关(r=0.517,P=0.000);OA患者关节液中瘦素浓度与Ayral评分呈正相关(r=0.327,P=0.035);骨关节炎患者血清中瘦素浓度与Ayral评分呈正相关(r=0.333,P=0.031);非骨关节炎患者关节液中瘦素浓度与Ayral评分呈正相关(r=0.311,P=0.023);非OA患者血清中瘦素浓度与Ayral评分呈正相关(r=0.397,P=0.003)。结论膝关节液及血清中瘦素含量可以反映关节滑膜的炎症程度,并且关节液比血清能更好地反映这种变化。

Correlation between severity of knee synovitis and levels of leptin in synovial fluid and serum

Objective To study the correlation between severity of knee synovitis and levels of leptin in synovial fluid and serum.Methods Synovial fluid and serum from 95 patients who underwent arthroscopic surgery were selected.ELISA was used to detect the levels of leptin which was detected by ELISA.Ayral score was used to evaluate the severity of knee synovitis under arthroscope.Results The leptin levels in synovial fluid and serum of osteoarthritis patients（39±9 ng/ml;26±8 ng/ml） was significantly higher than those of non-osteoarthritis patients（17±6 ng/ml;19±8 ng/ml）（P0.05）.The Ayral score was positively correlated with synovial（r= 0.678,P=0.000） and serum level of leptin（r=0.517,P=0.000） in all patients,synovial（r=0.327,P=0.035） and serum（r=0.333,P=0.031） level of leptin in OA patients,and synovial（r=0.311,P=0.023） and serum（r=0.397,P=0.003） level of leptin in non-OA patients.Conclusion The synovial or serum level of leptin may reflect severity of knee synovitis.Synovial level of leptin may be more sensitive to the disease.