| 正交设计优选当归苦参丸仿生提取工艺 |
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| 引用本文： | 刘文虎,刘毅,贺殿. 正交设计优选当归苦参丸仿生提取工艺[J]. 中国药师, 2011, 14(3): 345-349 |
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| 作者姓名： | 刘文虎 刘毅 贺殿 |
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| 作者单位： | 1. 川北医学院药理教研室,四川南充,637000
2. 兰州大学药学院药物化学研究所 |
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| 摘 要： | 目的:探索当归苦参丸的新型仿生提取方法。方法:采用液-液连续萃取法,用酸水、碱水模拟胃肠环境,以正辛醇模拟生物膜结构,以阿魏酸和苦参碱提取效率为考察指标,采用L8（34）正交试验法,探讨酸（碱）水体积、pH及蒸馏时间对阿魏酸、苦参碱提取的影响。结果:模拟胃环境仿生提取最佳工艺为A1B1D3,即酸水4倍量,pH为1,蒸馏时间6 h;模拟肠环境仿生提取最佳工艺为A1B3D3,即碱水4倍量,pH为9,蒸馏时间6 h。结论:仿生提取法提取阿魏酸、苦参碱简便、可行。
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| 关 键 词： | 当归苦参丸 仿生提取 阿魏酸 苦参碱 正交设计 |
Optimization of Novel Bionic Extraction Technology of Danggui Kushen Pills by Orthogonal Design |
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| Liu Wenhu,Liu Yi,He Dian. Optimization of Novel Bionic Extraction Technology of Danggui Kushen Pills by Orthogonal Design[J]. China Pharmacist, 2011, 14(3): 345-349 |
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| Authors: | Liu Wenhu Liu Yi He Dian |
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| Affiliation: | Liu Wenhu~1,Liu Yi~1,He Dian~2(1.Department of Pharmacology,North Sichuan Medical College,Sichuan Nanchong 637000,China,2. Institute of Medicinal Chemistry,School of Pharmacy,Lanzhou University) |
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| Abstract: | Objective:To explore a novel bionic extraction of Danggui Kushen pills.Method:Danggui Kushen pills were extracted by a novel bionic extraction method,in which acidic or basic water simulated the condition of stomach and intestine and n-octanol simulated the structure of biomemberane.The effects of acidic or basic water volume,pH and the distillation time on the extraction rate of ferulic acid and sophor carpidine content were evaluated by orthogonal design L_9(3~4).Result:The optimum extraction technology w... |
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| Keywords: | Danggui Kushen pills Bionic extraction Ferulic acid Sophor carpidine Orthogonal design |
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