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| 痛风宁分散片的制备及溶出度测定 | |
| 引用本文： | 冯井庆,张琼光,熊富良,高文天,丁英平.痛风宁分散片的制备及溶出度测定[J].中国药师,2011,14(3):394-396. |
| 作者姓名： | 冯井庆 张琼光 熊富良 高文天 丁英平 |
| 作者单位： | 1. 武汉理工大学化学工程学院,武汉,430070 2. 武汉大学医学院病毒学研究所 3. 湖北中医药大学 |
| 摘 要： | 目的:制备痛风宁分散片,并考察其体外溶出度。方法:以分散均匀性为考察指标,考察崩解剂的种类及用量、润滑剂的用量及加入方式;通过吸湿性试验测定临界相对湿度;以别嘌醇及苯溴马隆为指标比较痛风宁分散片与通益风宁片的溶出度。结果:优选的崩解剂为8.8%CMS-Na,41.6%MCC,润滑剂为1.6%微粉硅胶。临界相对湿度为73.5%。痛风宁分散片较普通片溶出快。结论:痛风宁分散片处方处方合理,工艺可行。 |
| 关 键 词： | 痛风宁分散片 处方优化 溶出度 |
Preparation and Dissolution of Tongfengning Dispersible Tablets |
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| Feng Jingqing,Zhang Qiongguang,Xiong Fuliang,Gao Wentian,Ding Yingping.Preparation and Dissolution of Tongfengning Dispersible Tablets[J].China Pharmacist,2011,14(3):394-396. | |
| Authors: | Feng Jingqing Zhang Qiongguang Xiong Fuliang Gao Wentian Ding Yingping |
| Institution: | Feng Jingqing~1,Zhang Qiongguang~2,Xiong Fuliang~1,Gao Wentian~1,Ding Yingping~3(1.School of Chemistry and Engineering,Wuhan University of Technology,Wuhan 430070,China,2.Institute of Medical Virology,School of Medicine of Wuhan University,3.Hubei University of Chinese Medicine) |
| Abstract: | Objective:To prepare the Tongfengning dispersible tablets and investigate the dissolution rate in vitro.Method:The dispersion uniformity was used as the index to study the type and amount of disintegrants,and the amount and addition method of the lubricant. Through the moisture absorption test,the critical relative humidity was determined.The allopurinol and benzbromarone was employed as the indicators to compare the release rates of Tongfengning tablets and Tongyi Fengning tablets.Result:The optimal disint... |
| Keywords: | Tongfengning dispersible tablets Optimization of formula Dissolution rate |
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