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| 正交设计法制备司帕沙星眼用凝胶 | |
| 引用本文： | 温坚,林三清,汪德凤,黄娜,洪宝贤,夏敬民. 正交设计法制备司帕沙星眼用凝胶[J]. 中国药师, 2011, 14(2): 228-231 |
| 作者姓名： | 温坚 林三清 汪德凤 黄娜 洪宝贤 夏敬民 |
| 作者单位： | 1. 湛江中心人民医院,广东湛江,524037 2. 湛江师范学院制药工程系 3. 湛江师范学院校医院 |
| 摘 要： | 目的:制备司帕沙星眼用凝胶。方法:以卡波姆-940为基质制备司帕沙星眼用凝胶。采用正交设计试验,以样品的黏稠度、透明度及pH为考察指标,优化处方配比。结果:所制制剂为淡黄色胶体,凝胶质量符合《中国药典》2010年版眼用凝胶的质量要求。司帕沙星眼用凝胶中卡波姆-940、甘油和1,2-丙二醇的最佳用量分别为0.4%、10%和6%。结论:司帕沙星眼用凝胶的制备工艺简单、可行。 |
| 关 键 词： | 司帕沙星 眼用凝胶 制备 正交设计 |
Preparation of Sparfloxacin Ophthalmic Gel by Orthogonal Design |
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| Wen Jian,Lin Sanqing,Wang Defeng,Huang Na,Hong Baoxian,Xia Jingmin. Preparation of Sparfloxacin Ophthalmic Gel by Orthogonal Design[J]. China Pharmacist, 2011, 14(2): 228-231 | |
| Authors: | Wen Jian Lin Sanqing Wang Defeng Huang Na Hong Baoxian Xia Jingmin |
| Affiliation: | Wen Jian~1,Lin Sanqing~2,Wang Defeng~3,Huang Na~2,Hong Baoxian~2,Xia Jingmin~2(1.Zhanjiang Central People' s Hospital,Guangdong Zhanjiang 524037,China,2.Pharmaceutical Engineering Department of Zhanjian Normal University,3.Hospital of Zhanjiang Normal University) |
| Abstract: | Objective:To prepare sparfloxacin ophthalmic gel.Method:Carbomer-940 was used as the base to prepare sparfloxacin ophthalmic gel.With the stickiness,opacity and pH of the gel as the assessment indices,the best formulation of sparfloxacin ophthalmic gel was screened by orthogonal design.Result:Sparfloxacin ophthalmic gel was light yellow colloid which accorded with the relative quality requirement in Chinese pharmacopoeia 2010.The best content of carbomer-940,glycerol and glycol propylene in the gel was 0.4%... |
| Keywords: | Sparfloxacin Ophthahnic gel Preparation Orthogonal design |
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